Delay
What is diabetes?
Diabetes, also called diabetes mellitus, is a disease that causes your blood glucose, or blood sugar, levels to be too high. There are three types of diabetes: type 1 diabetes, gestational diabetes, and type 2 diabetes. Type 2 diabetes is the most common type and may be prevented, delayed, or managed by making lifestyle changes.
What is type 2 diabetes?If you have type 2 diabetes, your body doesn't make enough insulin or doesn't use it well. This is called insulin resistance. Insulin is a hormone that helps glucose get into your cells. Glucose is your cells' main source of energy and comes from the foods you eat. If your body is resistant to insulin, then insulin can't get enough glucose into your cells. This then leads to glucose staying in your blood, leading to high blood glucose levels.
Over time, having too much glucose in your blood can cause health problems. If you are at risk for type 2 diabetes, you might be able to prevent or delay developing it.
Who is at risk for type 2 diabetes?Many people are at risk for type 2 diabetes. Your chances of getting it depend on a combination of risk factors such as your genes and lifestyle. The risk factors include:
- Having prediabetes, which means you have blood glucose levels that are high for you, but not high enough to be called diabetes
- Being overweight or having obesity
- Being age 35 or older
- A family history of diabetes
- Being African American, Alaska Native, American Indian, Asian American, Hispanic/Latino, Native Hawaiian, or Pacific Islander
- Having high blood pressure
- Having a low level of HDL (good) cholesterol or a high level of triglycerides
- A history of diabetes in pregnancy
- Having given birth to a baby weighing 9 pounds or more
- An inactive lifestyle
- A history of heart disease or stroke
- Having depression
- Having polycystic ovary syndrome (PCOS)
- Having acanthosis nigricans, a skin condition in which your skin becomes dark and thick, especially around your neck or armpits
- Smoking
Most of the things that you need to do to prevent or delay getting type 2 diabetes involve having a healthier lifestyle. Lifestyle changes include:
- Lose weight.Weight control is an important part of diabetes prevention. You may be able to prevent or delay diabetes by losing 5 to 7% of your current weight. For example, if you weigh 200 pounds, your goal would be to lose between 10 to 14 pounds. And once you lose the weight, it is important that you don't gain it back.
- Follow a healthy eating plan. It is important to reduce the amount of calories you eat and drink each day, so you can lose weight and keep it off. To do that, your diet should include smaller portions and less fat and sugar. You should also eat a variety of foods from each food group, including plenty of whole grains, fruits, and vegetables. It's also a good idea to limit red meat and avoid processed meats.
- Get regular exercise. Being physically active has many health benefits, including helping you to lose weight and lower your blood glucose levels. These both lower your risk of type 2 diabetes. Try to get at least 30 minutes of physical activity on most days of the week. The amount of exercise you need depends on your age and health. Even small amounts of exercise can be helpful. If you have not been active, talk with your health care provider to figure out which types of exercise are best for you. You can start slowly and work up to your goal.
- Don't smoke. Smoking can contribute to insulin resistance, which can lead to type 2 diabetes. If you already smoke, try to quit.
- Talk to your provider to see whether there is anything else you can do to delay or to prevent type 2 diabetes. If you are at high risk, your provider may suggest that you take one of a few types of diabetes medicines.
If you make these changes, you will get other health benefits as well. You may lower your risk of other diseases, and you will probably feel better and have more energy.
NIH: National Institute of Diabetes and Digestive and Kidney Diseases
Delay FDA Approved Drugs
- As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
- Lowering plasma glucagon in a subject in need thereof, including one with type 2 diabetes, by administering an exendin or analog, such as exendin-4.
- Method for treating type 2 diabetes using a sustained-release composition containing exenatide.
- Reducing food intake in a subject with type 2 diabetes by administering an exendin, such as exendin-4.
- Reducing gastric motility or delaying gastric emptying by administering an exendin, such as exendin-4.
- Reductions in body weight are observed with exenatide.
- Treating type 2 diabetes mellitus with exenatide by stimulating insulin release.
- Treatment of type 2 diabetes.
- As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
- Lowering plasma glucagon in a subject in need thereof, including one with type 2 diabetes, by administering an exendin or analog, such as exendin-4.
- Method for treating type 2 diabetes using a sustained-release composition containing exenatide.
- Reducing food intake in a subject with type 2 diabetes by administering an exendin, such as exendin-4.
- Reducing gastric motility or delaying gastric emptying by administering an exendin, such as exendin-4.
- Reductions in body weight are observed with exenatide.
- Treating type 2 diabetes mellitus with exenatide by stimulating insulin release.
- Treatment of type 2 diabetes.
- Lowering plasma glucagon in a subject in need thereof, including one with type 2 diabetes, by administering an exendin or analog, such as exendin-4.
- Reducing food intake in a subject with type 2 diabetes by administering an exendin, such as exendin-4.
- Reducing gastric motility or delaying gastric emptying by administering an exendin, such as exendin-4.
- Stimulating insulin release by administering exenatide.
- Treating type 2 diabetes mellitus with exenatide by stimulating insulin release.
- Use of exenatide may result in reduction in appetite..
- Use of exenatide may result in reduction in body weight.
- To treat or prevent infections caused by susceptible bacteria using delayed-release tablets consisting of doxycycline hyclate coated pellets in a tablet.
- To treat or prevent infections caused by susceptible bacteria using delayed-release tablets consisting of doxycycline hyclate coated pellets in a tablet.
- Treatment of diseases or conditions by the use of a delayed release 1, 2, or 5 mg prednisone tablet.
- Treatment of diseases or conditions by the use of a delayed-release 1,2, or 5mg prednisone tablet.
- Treatment of pulmonary, gastrointestinal and/or rheumatological diseases or conditions by use of delayed release formulations of 1mg or 2mg prednisone.
- Treatment of rheumatoid arthritis by delayed release formulation of 1mg or 2mg of prednisone.
- Treatment of rheumatologic, allergic, pulmonary, gastrointestinal, dermatologic diseases or conditions by the use of a delayed release 5mg prednisone tablet.
- Prevention of delayed nausea and vomiting associated with emetogenic cancer chemotherapy.
Felter's Materia Medica on Delay
   The rhizome and roots of Caulophyllum thalictroides (Linné, Michaux (Nat. Ord. Berberidaceae). In rich woods in the eastern half of the United... / ... when that agent was so popular and so damaging as an oxytocic. It may be used to assist labor when delay is due to weakness, fatigue, or lack of uterine power, or when the tissues feel full, as if co... / ...of strength and rapid involution of the womb following labor. The dose of the syrup is from 2 fluidrachms to 1/2 fluidounce, 2 or 3 times a day.1
   The full grown fruit, gathered green, of Conium maculatum, Linné (Nat. Ord. Umbelliferae). Europe and Asia; naturalized in the United... / ...ly not cancerous, but more than likely of a strumous character. At any rate we are not justified in delaying necessary measures by a long course of conium medication with uncertain prospects of relief...1
   The rhizome and rootlets of Cimicifuga racemosa (Linné), Nuttall (Nat. Ord. Ranunculaceae). A conspicuously handsome perennial widely found in... / ...; false pains; afterpains; weak, irregular uterine contractions during labor; irregular, scanty, or delayed menstruation, with dull pain and muscular soreness; chorea, with absentio mensium; and rheum...1
   The dried leaflets of (1) Pilocarpus Jaborandi, Holmes; or (2) Pilocarpus microphyllus, Stapf (Nat. Ord. Rutaceae). Brazil and Paraguay. Dose, 20... / ...he termination of sweating temperature regains its normal status, usually at once, but is sometimes delayed for several hours. As a rule, the secretion of milk is believed to be unaffected by pilocarp... / ...bronchial and lachrimal flow. The saliva contains an abundance of ptyalin and salts and readily converts starch into sugar. At times the mucous 1
   The leaves and tops of Tanacetum vulgare, Linné (Nat. Ord. Compositae). Europe; naturalized and cultivated in the United States. Dose, 5 to 60... / ...y is a uterine stimulant and emmenagogue, and is a popular but unsafe remedy to restore arrested or delayed menstruation. An infusion is generally employed for this purpose by the laity. The cold infu...1
Physician's Therapeutics Memoranda on Delay
   To overcome uterine inertia, kola is of value; to delay parturition, morphine and bromides; to relax os uteri, chloral and morphine; to hasten delivery, ergot; for post partum hemorrhage, mechanical stimulation of the uterus to cause contraction, ergot; as anesthetic, chloroform or ethyl bromide.2
References
2) Nelson, Baker & Co., 1904, Physician's Handy Book of Materia Medica and Therapeustics, Detroit, Michigan.
