Diabetes
What is diabetes?
Diabetes, also known as diabetes mellitus, is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose is your body's main source of energy. Your body can make glucose, but it also comes from the food you eat. Insulin is a hormone made by your pancreas. Insulin helps move glucose from your bloodstream into your cells, where it can be used for energy.
If you have diabetes, your body can't make insulin, can't use insulin as well as it should, or both. Too much glucose stays in your blood and doesn't reach your cells. This can cause glucose levels to get too high. Over time, high blood glucose levels can lead to serious health conditions. But you can take steps to manage your diabetes and try to prevent these health problems.
What are the types of diabetes?There are different types of diabetes:
- Type 1 diabetes. If you have type 1 diabetes, your body makes little or no insulin. It happens when your immune system attacks and destroys the cells that produce insulin.
- Type 2 diabetes. This is the most common form of diabetes. If you have type 2 diabetes, your body may still be able to make insulin, but your cells don't respond well to insulin. They can't easily take up enough glucose from your blood.
- Gestational diabetes. This is a form of diabetes that develops during pregnancy. It happens when your body can't make the extra insulin it needs during pregnancy.
The different types of diabetes have different causes:
- Researchers think type 1 diabetes is caused by genes and factors in the environment that might trigger the disease.
- Type 2 diabetes is caused by several factors, including lifestyle factors and genes. The lifestyle factors include not being physically active and being overweight or having obesity.
- Researchers think gestational diabetes is caused by the hormonal changes of pregnancy along with genetic and lifestyle factors.
The different types of diabetes have different risk factors:
- You can develop type 1 diabetes at any age, but it most often starts in childhood. Having a parent or sibling with type 1 diabetes may increase your chance of developing it.
- You are at higher risk of developing type 2 diabetes if you:
- Are overweight or have obesity.
- Are over age 35. Children, teenagers, and younger adults can get diabetes, but it is more common in middle-aged and older adults.
- Have a family history of diabetes.
- Have prediabetes. This means that your blood glucose is higher than normal, but it's not high enough to be called diabetes.
- Had gestational diabetes.
- Have given birth to a baby weighing 9 pounds or more.
- Are African American, American Indian, Asian American, Hispanic/Latino, or Pacific Islander.
- Are not physically active.
- Have certain other health conditions, such as high blood pressure or polycystic ovary syndrome (PCOS).
- You are at higher risk of developing gestational diabetes if you:
- Are overweight or have obesity.
- Have a family history of diabetes.
- Had gestational diabetes in a previous pregnancy.
- Have given birth to a baby weighing 9 pounds or more.
- Have polycystic ovary syndrome (PCOS).
- Are African American, Hispanic/Latino, American Indian, Alaska Native, Native Hawaiian, or Pacific Islander.
The symptoms of diabetes may include:
- Feeling very thirsty
- Feeling very hungry
- Urinating (peeing) more often, including at night
- Fatigue
- Blurry vision
- Numbness or tingling in the feet or hands
- Sores that do not heal
- Losing weight without trying
But it's important to know that your symptoms may vary, depending on which type you have:
- The symptoms of type 1 diabetes usually come on quickly and can be severe.
- With type 2 diabetes, the symptoms often develop slowly, over several years. The symptoms can be so mild that you might not even notice them.
- Gestational diabetes often has no symptoms. If you do have symptoms, they may be mild. People who are pregnant are usually screened for this condition between 24 and 28 weeks of pregnancy.
To find out if you have diabetes, your health care provider will use one or more glucose blood tests. There are several types, including the A1C test.
What are the treatments for diabetes?Treatment for diabetes involves managing your blood glucose levels:
- If you have type 1 diabetes, you will need to take daily doses of insulin, either by injection or through a special pump. Some people also need to take another type of diabetes medicine that works with insulin.
- If you have type 2 diabetes, you may be able to manage or even reverse it by making lifestyle changes. These include eating a healthy diet, staying at healthy weight, and getting regular physical activity. Some people also need to take diabetes medicines to manage their diabetes.
- If you have gestational diabetes, you may be able to lower your glucose levels by eating a healthy diet and getting regular exercise. But be sure to talk to your provider about your treatment options. Gestational diabetes usually goes away after you give birth. But you will have a higher risk of developing type 2 diabetes later.
Checking your blood glucose levels is also an important part of managing your diabetes. Ask your provider about the best way to check your blood glucose level and how often you should check it.
Can diabetes be prevented?Type 1 diabetes can't be prevented.
You may be able to delay or prevent type 2 diabetes through the same lifestyle changes that are used to manage diabetes (eating a healthy diet, staying at a healthy weight, and getting regular physical activity). These lifestyle changes may also help prevent gestational diabetes.
NIH: National Institute of Diabetes and Digestive and Kidney Diseases
Diabetes FDA Approved Drugs
- Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who are already treated with pioglitazone and metformin or who have inadequate glycemic control on pioglitazone or metformin alone.
- Adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes who are already treated with a pioglitazone and metformin.
- To reduce gastrointestinal side effects administer with a meal; as starting dose administer once daily with evening meal.
- Combination treatment with a glitazone for improvement of glycemic control in type 2 diabetes mellitus patients.
- Improvement in glycemic control in type 2 diabetes mellitus patients by use of a pen injector.
- Administration of a composition comprising insulin complexed with a diketopiperazine..
- Administration of a composition comprising insulin complexed with microparticles of a diketopiperazine..
- Administration of fdkp microparticles comprising insulin..
- Method of aerosolizing/deagglomerating an insulin dry powder for use in treating diabetes mellitus via oral inhalation using an inhaler with a cartridge containing the insulin dry powder..
- Method of controlling glycemia in diabetics by administering an initial dose of insulin-fdkp with a meal; determining blood glucose level 1-2 hrs after and administering a supplemental dose of insulin-fdkp if postprandial glucose level is >140 mg/dl.
- Method of delivering to a patient with diabetes mellitus in a single inhalation, greater than 75% of a dry powder dose comprising insulin and fumaryl diketopiperazine using a high resistance to flow dry powder inhaler..
- Pulmonary administration of a compisition comprising insulin bound to a diketopiperazine..
- Pulmonary administration of a composition comprising insulin bound to a complexing agent..
- Pulmonary administration of an insulin composition comprising fdkp at the beginning of a meal to a patient also being treated with a long-acting insulin..
- Treatment of a patient having diabetes mellitus with a prandial rapid acting insulin..
- Treatment of diabetes mellitus with an inhaled insulin to improve glycemic control using a dry powder inhalation system comprising an inhaler, a cartridge and a dry powder medicament comprising insulin in a single inhalation.
- Treatment of patient having diabetes mellitus via oral inhalation of fdkp microparticles comprising insulin.
- Use of an inhaler to administer dry powder medicament.
- Improvement in glycemic control in diabetes mellitus patients by use of a pen injector with a threaded drive sleeve.
- Method of treating a patient suffering from diabetes mellitus.
- Improvement in glycemic control in diabetes mellitus patients by use of a pen injector with a threaded drive sleeve.
- Method of treating a patient suffering from diabetes mellitus.
- Method of treatment of type ii diabetes.
- As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
- Lowering plasma glucagon in a subject in need thereof, including one with type 2 diabetes, by administering an exendin or analog, such as exendin-4.
- Method for treating type 2 diabetes using a sustained-release composition containing exenatide.
- Reducing food intake in a subject with type 2 diabetes by administering an exendin, such as exendin-4.
- Reducing gastric motility or delaying gastric emptying by administering an exendin, such as exendin-4.
- Reductions in body weight are observed with exenatide.
- Treating type 2 diabetes mellitus with exenatide by stimulating insulin release.
- Treatment of type 2 diabetes.
- As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
- Lowering plasma glucagon in a subject in need thereof, including one with type 2 diabetes, by administering an exendin or analog, such as exendin-4.
- Method for treating type 2 diabetes using a sustained-release composition containing exenatide.
- Reducing food intake in a subject with type 2 diabetes by administering an exendin, such as exendin-4.
- Reducing gastric motility or delaying gastric emptying by administering an exendin, such as exendin-4.
- Reductions in body weight are observed with exenatide.
- Treating type 2 diabetes mellitus with exenatide by stimulating insulin release.
- Treatment of type 2 diabetes.
- Lowering plasma glucagon in a subject in need thereof, including one with type 2 diabetes, by administering an exendin or analog, such as exendin-4.
- Reducing food intake in a subject with type 2 diabetes by administering an exendin, such as exendin-4.
- Reducing gastric motility or delaying gastric emptying by administering an exendin, such as exendin-4.
- Stimulating insulin release by administering exenatide.
- Treating type 2 diabetes mellitus with exenatide by stimulating insulin release.
- Use of exenatide may result in reduction in appetite..
- Use of exenatide may result in reduction in body weight.
- Administration once daily within two hours after waking in the morning for improvement of glycemic control in a type 2 diabetes patient.
- Improvement of glycemic control in individuals with type 2 diabetes.
- Improvements of glycemic control in individuals with type 2 diabetes who have one or more specified cardiovascular risk factors.
- Treatment of type 2 diabetes by administering bromocriptine mesylate and a first-phase insulin secretagogue wherein the combined therapeutic effect is greater than the additive effect of administering each agent alone.
- As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes.
- Treatment of type 2 diabetes mellitus in a patient, wherein glycemic control (hba1c < 7.0%) is not achievable using one or more of insulin, metformin, pioglitazone, or rosiglitazone.
- Treatment of type 2 diabetes mellitus.
- Method of treating patient with type 2 diabetes by once daily administration.
- Treatment of type 2 diabetes.
- Indication of type ii diabetes.
- Method of treating type 2 diabetes mellitus by administering linagliptin in combination with empagliflozin (with or without insulin or a sulfonylurea).
- Method of treating type 2 diabetes mellitus by administering linagliptin in combination with empagliflozin (with or without metformin).
- Method of treating type 2 diabetes mellitus by administering linagliptin in combination with empagliflozin and metformin.
- Method of treating type 2 diabetes mellitus by administering linagliptin in combination with empagliflozin.
- Treatment of type 2 diabetes mellitus.
- Treatment of type 2 diabetes mellitus.
- Treatment of type 2 diabetes mellitus.
- Improvement of glycemic control in adults with type 2 diabetes mellitus.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-4 inhibitor in combination with insulin.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-4 inhibitor in combination with metformin and a ppar-gamma agonist.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-iv inhibitor in combination with metformin.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-iv inhibitor.
- Improvement of glycemic control in adults with type 2 diabetes mellitus.
- Method of treating type 2 diabetes mellitus in patients for whom treatment with both sitagliptin and metformin hcl extended release is appropriate.
- Improvement of glycemic control in adults with type 2 diabetes mellitus in combination with metformin and/or a ppar-gamma agonist and/or sulfonylurea and/or insulin.
- Improvement of glycemic control in adults with type 2 diabetes mellitus in combination with metformin..
- Improvement of glycemic control in adults with type 2 diabetes mellitus.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-4 inhibitor in combination with insulin.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-4 inhibitor in combination with metformin and a ppar-gamma agonist.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-iv inhibitor in combination with a ppar-gamma agonist.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-iv inhibitor in combination with metformin and/or a sulfonylurea.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-iv inhibitor.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidaste-iv inhibitor.
- Method of treating type 2 diabetes mellitus by administering linagliptin in combination with empagliflozin.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-4 inhibitor in combination with metformin.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-iv inhibitor in combination with metformin and/or a sulfonylurea.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-iv inhibitor.
- Method of treating type 2 diabetes mellitus by administering linagliptin in combination with metformin.
- Method of treating type 2 diabetes in patients who have not been previously treated with an antihyperglycemic agent by administering linagliptin in combination with metformin.
- Method of treating type 2 diabetes in patients with insufficient glycemic control despite therapy with one or more conventional antihyperglycemic agents by administering linagliptin in combination with metformin.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-iv inhibitor in combination with metformin and, optionally, a sulfonylurea.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-iv inhibitor in combination with metformin.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-iv inhibitor.
- Method of treating type 2 diabetes mellitus by administering linagliptin in combination with metformin.
- Method of treating type 2 diabetes.
- Method of treating diabetes comprising administering a compound such as alogliptin.
- Method of treating diabetes comprising administering alogliptin.
- Methods of lowering elevated post prandial blood glucose levels comprising administering a dipeptidyl peptidase inhibitor.
- Methods of modifying glucose metabolism and treating diabetes comprising administering a dipeptidyl peptidase inhibitor and one or more other therapeutic agents such as metformin.
- Methods of reducing the side effects of active components administered to a diabetic patient comprising administering an insulin sensitivity enhancer such as pioglitazone in combination with an insulin secretion enhancer.
- Methods of treating diabetes comprising administering a dipeptidyl peptidase inhibitor and metformin.
- Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both saxagliptin and metformin is appropriate.
- Method for treating type ii diabetes mellitus by administering saxagliptin in combination with metformin.
- Improvement in glycemic control in diabetes mellitus patients by use of a pen injector with a threaded drive sleeve.
- Improvement in glycemic control in diabetes mellitus patients by use of a pen injector with a threaded drive sleeve.
- Levemir is a long-acting basal insulin analog that is indicated in the treatment of patients with diabetes mellitus.
- Levemir is a long-acting basal insulin analog that is indicated in the treatment of patients with diabetes mellitus.
- Method of treating diabetes comprising administering a compound such as alogliptin.
- Method of treating diabetes comprising administering alogliptin.
- Methods of lowering elevated post prandial blood glucose levels comprising administering a dipeptidyl peptidase inhibitor.
- Methods of modifying glucose metabolism and treating diabetes comprising administering a dipeptidyl peptidase inhibitor and one or more other therapeutic agents such as metformin.
- Methods of reducing the side effects of active components administered to a diabetic patient comprising administering an insulin sensitivity enhancer such as pioglitazone in combination with an insulin secretion enhancer.
- Methods of treating diabetes comprising administering a dipeptidyl peptidase inhibitor and metformin.
- Method for treating type ii diabetes by administering saxagliptin.
- Method for treating type ii diabetes mellitus by administering saxagliptin alone or in combination with insulin, metformin, a thiazolidinedione, glyburide or metformin plus a sulfonylurea.
- Method of treating diabetes comprising administering a compound such as alogliptin.
- Method of treating diabetes comprising administering alogliptin.
- Methods of lowering elevated post prandial blood glucose levels comprising administering a dipeptidyl peptidase inhibitor.
- Methods of modifying glucose metabolism and treating diabetes comprising administering a dipeptidyl peptidase inhibitor and one or more other therapeutic agents such as metformin.
- Methods of reducing the side effects of active components administered to a diabetic patient comprising administering an insulin sensitivity enhancer such as pioglitazone in combination with an insulin secretion enhancer.
- Methods of treating diabetes comprising administering an insulin sensitivity enhancer such as pioglitazone in combination with an insulin secretion enhancer.
- Methods of treating diabetes comprising administering a dipeptidyl peptidase inhibitor and metformin.
- Method for treating type 2 diabetes mellitus (t2dm) in patients who are already treated with dapagliflozin and saxagliptin.
- Method for treating type 2 diabetes mellitus (t2dm) in patients who have inadequate control with dapagliflozin.
- Improvement in glycemic control in adults with type 2 diabetes mellitus inadequately controlled by basal insulin or lixisenatide by use of a pen injector with a threaded drive sleeve.
- Use as a blood glucose-lowering agent.
- Use for treatment of diabetes, particularly type 2 diabetes.
- Treatment of diabetes with an amylin agonist, including with insulin.
- Treatment of diabetes with an amylin agonist.
- Use of an amylin agonist to reduce gastric motility and treat post prandial hypergylcemia.
- Improvement in glycemic control in diabetes mellitus patients by use of a pen injector with a threaded drive sleeve.
- Improvement in glycemic control in diabetes mellitus patients.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-4 inhibitor in combination with pioglitazone.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-4 inhibitor in combination with sulfonlyurea.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-iv inhibitor in combination with metformin and/or a sulfonylurea.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidaste-iv inhibitor.
- Method of treating type 2 diabetes mellitus by administering linagliptin in combination with insulin (with or without metformin and/or pioglitazone).
- Method of treating type 2 diabetes mellitus by administering linagliptin in combination with metformin.
- Method of treating type 2 diabetes mellitus by administering linagliptin.
- Method of treating type 2 diabetes mellitus in patients with severe chronic renal impairment and for whom metformin therapy is inappropriate by administering linagliptin.
- Method of treating type 2 diabetes mellitus in patients with severe chronic renal impairment and who are ineligible for metformin therapy by administering linagliptin.
- Treatment of type 2 diabetes mellitus.
- A method for improving glycemic control in adults with type 2 diabetes mellitus.
- Treatment of type 2 diabetes mellitus.
- Treatment of type 2 diabetes mellitus in a patient, wherein glycemic control (hba1c < 7.0%) is not achievable using one or more of insulin, metformin, pioglitazone, or rosiglitazone.
- Treatment of type 2 diabetes mellitus.
Felter's Materia Medica on Diabetes
   The fungus Amanita muscaria, Persoon; (Agaricus muscarius, Linné.) (Nat. Ord. Fungi.) An extremely poisonous fungus found in the pine forests of... / ... and profuse sweating in the daytime; and to restrain the excess of urine in polyuria, or so-called diabetes insipidus. Scudder suggested a tincture of the fresh fungus for involuntary twitching of ... / ...by Eclectic practitioners. Muscarine is used in atropine and belladonna poisoning, sometimes being employed in place of eserine (physostigmine). 1
   The unripe seed of the Avena sativa, Linné, and the farina derived from the ripened seed (Nat. Ord. Graminaceae). Probably indigenous to Sicily... / ...t should be about the consistence of milk. Oatmeal gruel, when not otherwise contraindicated, as in diabetes mellitus or amylaceous indigestion, is an excellent and easily digested food in convalescen... / ...off the habit has not been sustained. In our own experience we have utterly failed to accomplish any good with it in any form of drug habit. 1
   ...ome effect upon the functions of the pancreas, it is probably of little value in that worst form of diabetes mellitus in which the cells of Langerhans are destroyed. It should be given renewed study i......sity and when sugar intolerance alone, and not starch disturbances, create what so often passes for diabetes. These are rather prediabetic conditions, if tending in that direction at all, but even if ...1
   The whole plant of Erigeron canadense, Linné (Nat. Ord. Compositae). A common and troublesome weed through the northern and central parts of the... / ...ive hemorrhage is present. It has restrained the pathologic flow of urine in polyuria, or so-called diabetes insipidus. The oil of erigeron is a good internal hemostatic. It sometimes checks quite sev... / ...Given in syrup it is useful as a cough medicine when there is bloody expectoration.1
   ...ion; albuminuria with the above characteristic circulatory disturbances; polyuria and some cases of diabetes with rapid heart action. Therapy.Lycopus is sedative, subastringent, and tonic. No other ......exaggerated force of the heart. It has been ill-advised, and is largely over-rated, for the cure of diabetes and the relief of chronic nephritis. The most it can do in these conditions is to allay unp...1
   ...ht it to have a restraining effect both upon the hypersecretion of urine and the output of sugar in diabetes. Apparently it is only in exceptional cases that it displays this power, and too much relia......h reliance should not be placed upon it in severe cases. As an aid to control some of the phases of diabetes, as excessive urination, it should be used in conjunction with other approved methods. Whil...1
Physician's Materia Medica on Diabetes
   Astringent but not locally hemostatic, Prescribed in diarrheas, in atonic albuminuria, in hematuria, colliquative sweats, diabetes insipidus (combined with opium) and in internal hemorrhages. Ap plied locally in ointments in hemorrhoids and for unhealthy ulcers. Dose, 0.2 to 1.0 Grm. (3 to 15 grs.)2
   A dense fluid remarkable for its strong aflinity for moisture. It is hence of great use as a local depletant, especially to mucous membranes. It is thus applied to the cervix uteri to relieve conges tion and on a similar principle is used in the form of suppositories to cause the bowels to move. In diabetes mellitus, it is sometimes used in place of sugar as a sweetening agent in articles of food.2
   The seeds of EUGENIA JAMBOLANA, Lam. Astringent, antizymotic; a remedy of great value in some forms of diabetes mellitus, greatly diminishing the excretion of sugar.2
   A derivative of NITRO-PHENOL. Analgesic. antipyretic. Prescribed for relief of pain in acute rheumatism, sciatica, gastralgia, migraine, dysmenorrhea, neuralgia. etc.; to reduce temperature and promote diaphoresis in fevers, and for a specific influence in diabetes. Dose, 0.12 to 0.60 Grm. (2 to 10 grs.).2
   Antispasmodic, nervine. Prescribed in neuralgia, nervous head ache, hysteria, whooping cough and diabetes insipidus. Dose, 0.06 to 0.12 Grm. (1 to 2 grs.).2
Physician's Therapeutics Memoranda on Diabetes
   If dependent on vaso-motor relaxation, ergot, extract suprarenal glands; astringents, particularly gallic acid and rhus aromatica. If due to nervous irritability, belladonna, nervines, bromides. Tonics are generally indicated, particularly iron and strychnine.2
   Exclude sugar and starch as far as possible from the diet, but do not starve the patient. The remedies most likely to be useful are; Solution Gold and Arsenic Bromide, Fl. Ext. J ambul seed, morphine o_r codeine (particularly Tablets of Codeine without sugar); in gouty cases, colchicine, iodides, lithium salts, and arsenic; in rheumatic cases, salicylic acid, salicylates, potassium iodide. Other remedies are methylene blue (2 to 5 grs. three times a day), uranium nitrate (2 grs. increased gradua...2
References
2) Nelson, Baker & Co., 1904, Physician's Handy Book of Materia Medica and Therapeustics, Detroit, Michigan.