Disease
What is fatty liver disease?
Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Fatty liver disease is a condition in which fat builds up in your liver. There are two main types:
- Nonalcoholic fatty liver disease (NAFLD)
- Alcoholic fatty liver disease, also called alcoholic steatohepatitis
NAFLD is a type of fatty liver disease that is not related to heavy alcohol use. There are two kinds:
- Simple fatty liver, in which you have fat in your liver but little or no inflammation or liver cell damage. Simple fatty liver typically does not get bad enough to cause liver damage or complications.
- Nonalcoholic steatohepatitis (NASH), in which you have inflammation and liver cell damage, as well as fat in your liver. Inflammation and liver cell damage can cause fibrosis, or scarring, of the liver. NASH may lead to cirrhosis or liver cancer.
Alcoholic fatty liver disease is due to heavy alcohol use. Your liver breaks down most of the alcohol you drink, so it can be removed from your body. But the process of breaking it down can generate harmful substances. These substances can damage liver cells, promote inflammation, and weaken your body's natural defenses. The more alcohol that you drink, the more you damage your liver. Alcoholic fatty liver disease is the earliest stage of alcohol-related liver disease. The next stages are alcoholic hepatitis and cirrhosis.
Who is at risk for fatty liver disease?The cause of nonalcoholic fatty liver disease (NAFLD) is unknown. Researchers do know that it is more common in people who:
- Have type 2 diabetes and prediabetes
- Have obesity
- Are middle aged or older (although children can also get it)
- Are Hispanic, followed by non-Hispanic Whites. It is less common in African Americans.
- Have high levels of fats in the blood, such as cholesterol and triglycerides
- Have high blood pressure
- Take certain drugs, such as corticosteroids and some cancer drugs
- Have certain metabolic disorders, including metabolic syndrome
- Have rapid weight loss
- Have certain infections, such as hepatitis C
- Have been exposed to some toxins
NAFLD affects about 25% of people in the world. As the rates of obesity, type 2 diabetes, and high cholesterol are rising in the United States, so is the rate of NAFLD. NAFLD is the most common chronic liver disorder in the United States.
Alcoholic fatty liver disease only happens in people who are heavy drinkers, especially those who have been drinking for a long period of time. The risk is higher for heavy drinkers who are women, have obesity, or have certain genetic mutations.
What are the symptoms of fatty liver disease?Both NAFLD and alcoholic fatty liver disease are usually silent diseases with few or no symptoms. If you do have symptoms, you may feel tired or have discomfort in the upper right side of your abdomen.
How is fatty liver disease diagnosed?Because there are often no symptoms, it is not easy to find fatty liver disease. Your doctor may suspect that you have it if you get abnormal results on liver tests that you had for other reasons. To make a diagnosis, your doctor will use:
- Your medical history
- A physical exam
- Various tests, including blood and imaging tests, and sometimes a biopsy
As part of the medical history, your doctor will ask about your alcohol use, to find out whether fat in your liver is a sign of alcoholic fatty liver disease or nonalcoholic fatty liver (NAFLD). He or she will also ask which medicines you take, to try to determine whether a medicine is causing your NAFLD.
During the physical exam, your doctor will examine your body and check your weight and height. Your doctor will look for signs of fatty liver disease, such as:
- An enlarged liver
- Signs of cirrhosis, such as jaundice, a condition that causes your skin and whites of your eyes to turn yellow
You will likely have blood tests, including liver function tests and blood count tests. In some cases you may also have imaging tests, like those that check for fat in the liver and the stiffness of your liver. Liver stiffness can mean fibrosis, which is scarring of the liver. In some cases you may also need a liver biopsy to confirm the diagnosis, and to check how bad the liver damage is.
What are the treatments for fatty liver disease?Doctors recommend weight loss for nonalcoholic fatty liver. Weight loss can reduce fat in the liver, inflammation, and fibrosis. If your doctor thinks that a certain medicine is the cause of your NAFLD, you should stop taking that medicine. But check with your doctor before stopping the medicine. You may need to get off the medicine gradually, and you might need to switch to another medicine instead.
There are no medicines that have been approved to treat NAFLD. Studies are investigating whether a certain diabetes medicine or Vitamin E can help, but more studies are needed.
The most important part of treating alcohol-related fatty liver disease is to stop drinking alcohol. If you need help doing that, you may want to see a therapist or participate in an alcohol recovery program. There are also medicines that can help, either by reducing your cravings or making you feel sick if you drink alcohol.
Both alcoholic fatty liver disease and one type of nonalcoholic fatty liver disease (nonalcoholic steatohepatitis) can lead to cirrhosis. Doctors can treat the health problems caused by cirrhosis with medicines, operations, and other medical procedures. If the cirrhosis leads to liver failure, you may need a liver transplant.
What are some lifestyle changes that can help with fatty liver disease?If you have any of the types of fatty liver disease, there are some lifestyle changes that can help:
- Eat a healthy diet, limiting salt and sugar, plus eating lots of fruits, vegetables, and whole grains
- Get vaccinations for hepatitis A and B, the flu and pneumococcal disease. If you get hepatitis A or B along with fatty liver, it is more likely to lead to liver failure. People with chronic liver disease are more likely to get infections, so the other two vaccinations are also important.
- Get regular exercise, which can help you lose weight and reduce fat in the liver
- Talk with your doctor before using dietary supplements, such as vitamins, or any complementary or alternative medicines or medical practices. Some herbal remedies can damage your liver.
Disease FDA Approved Drugs
- Indicated for the relief of bronchospasm in patients 2-12 years of age with asthma (reversible obstructive airway disease).
- Method of decreasing the production of a-beta using a composition which decreases blood cholesterol in patients at risk of or exhibiting symptoms of alzheimer's disease.
- Maintenance treatment of asthma as prophylactic therapy in adult and adolescent patients 12 years of age and older. patent claims method for treating a respiratory disease in a child.
- Method of treating inflammatory conditions.
- Indicated for the long-term, once-daily, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (copd), including chronic bronchitis and/or emphysema..
- The long term, once-daily maintenance bronchodilator treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (copd), including chronic bronchitis and/or emphysema.
- Temporary reduction of fever.
- Temporary relief of minor aches and pains.
- Treatment/prevention of cardiovascular disease.
- Treatment of a neurodegenerative disease or a symptom thereof.
- Treatment of parkinson's disease.
- Use in the long-term, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (copd).
- Method of inhibiting platelet aggregation.
- Reduction of the rate of cardiovascular death, myocardial infarction, and stroke in patients with a history of myocardial infarction.
- Reduction of the rate of cardiovascular death, myocardial infarction, and stroke in patients with acute coronary syndrome or a history of myocardial infarction.
- Reduction of the rate of thrombotic events in patients with acute coronary syndrome.
- Treatment of an arterial thrombotic complication in a patient with coronary artery, cerebrovascular or peripheral vascular disease.
- Treatment of arterial thrombotic complications selected from the group consisting of unstable angina, thrombotic or embolic stroke, transient ischaemic attacks, peripheral vascular disease and myocardial infarction.
- Treatment of myocardial infarction and stroke in patients with acute coronary syndrome or a history of myocardial infarction.
- Treatment of myocardial infarction in patients with acute coronary syndrome or a history of myocardial infarction.
- Treatment of myocardial infarction.
- Treatment of post-myocardial infarction.
- Treatment of stable and unstable angina.
- Treatment of stroke in patients with acute coronary syndrome or a history of myocardial infarction.
- Treatment of stroke.
- Treatment of thrombotic stroke.
- For the long term treatment, twice daily (morning and evening) maintenance treatment of bronchoconstriction in patients with chronic obstructive pulmonary disease (copd), including chronic bronchitis and emphysema.
- Treatment of gaucher disease type 1.
- Treatment of parkinson's disease.
- Treatment of pediatric patients 8 to 17 years of age with heterozygous familial hypercholesterolemia (hefh).
- Use of rosuvastatin calcium for the primary prevention of cardiovascular disease in individuals without clinically evident coronary heart disease but with increased risk factors.
- Use of rosuvastatin calcium to reduce elevated total-c, ldl-c, apob, nonhdl-c or tg levels; to increase hdl-c in adult patients with primary hyperlipidemia or mixed dyslipidemia; and to slow the progression of atherosclerosis..
- For healing of all grades of erosive esophagitis (ee).
- For the treatment of heartburn associated with symptomatic non-erosive gastroesophageal disease (gerd).
- Healing of all grades of erosive esophagitis (ee) for up to 8 weeks.
- Maintain healing of erosive esophagitis (ee) for up to 6 months.
- To maintain healing of ee and relief of heartburn.
- Treatment of heartburn associated with non-erosive gastroesophageal reflux disease (gerd) for 4 weeks.
- Use of dexlansoprazole in patients taking clopidogrel without meaningful cyp2c19 interactions.
- Maintain healing of erosive esophagitis (ee) for up to 6 months.
- Treatment of heartburn associated with non-erosive gastroesophageal reflux disease (gerd) for 4 weeks.
- A method of catalyzing the hydrolysis of glucocerebroside to glucose and ceramide..
- A method of treating gaucher's disease.
- Treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following antiestrogen therapy.
- Treatment of hr-positive, human epidermal growth factor receptor 2 (her2)-negative advanced or metastatic breast cancer in combination with palbococlib in women with disease progression after endocrine therapy.
Shire LlcNov 23, 2005
- To reduce serum phosphate in patients with end stage renal disease.
- Treatment of autoimmune disease.
- Treatment of cancer.
- Treatment of patients with advanced (metastatic) non-small cell lung cancer whose disease progressed during or after platinum-based chemotherapy.
- A method for treating a tumor disease.
- Gleevec is also indicated for the treatment of patients with kit (cd117) positive unresectable and/or metastatic malignant gastrointestinal stromal tumors (gist).
- Treatment of gastrointestinal stromal tumors (gist).
- Treating hr-pos., her2-neg. advanced or metastatic breast cancer with palbociclib in combo with an aromatase inhibitor as initial endocrine based therapy in postmenopausal women or fulvestrant in women with disease progression after endocrine therapy.
- Indicated for the long-term, once-daily, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (copd), including chronic bronchitis and/or emphysema..
- Method of treating, reducing the incidence of, or preventing an ischemic event in a patient undergoing pci by administering intravenously 30 ug/kg bolus before pci and continuous infusion of 4 ug/kg/min for at least 2 hours or the duration of the pci.
- P2y12 platelet inhibitor for use as adjunct to percutaneous coronary intervention to reduce risk of various diseases/conditions in patients not treated with a p2y12 platelet inhibitor and not given a glycoprotein iib/iiia inhibitor.
- Kyprolis is indicated in combination with lenalidomide plus dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy.
- Treatment of patients with multiple myeloma who have received at least two prior therapies including bortezomib and an immunomodulatory agent and have demonstrated disease progression on or within 60 days of completion of the last therapy.
- Treatment of adult patients with philadelphia chromosome-negative(ph-) acute lymphoblastic leukemia (all) in second or greater relapse or whose disease has progressed following two or more anti-leukemia therapies.
- Treatment of parkinson's disease.
- Management of risk of dronedarone/beta-blocker interaction in patients in sinus rythm with a history of paroxysmal or persistent af.
- Reduction in risk of hospitalization in patients with a history of paroxysmal or persistent af without severe heart failure and with one or more risk factors by administration twice a daily with morning and evening meals.
- Reduction in risk of hospitalization in patients with coronary heart disease and a history of paroxysmal or persistent af and with one or more risk factors by administration twice a day with morning and evening meals.
- Reduction in risk of hospitalization in patients with stable nyha class iii heart failure and a history of paroxysmal or persistent af and with one or more risk factors by administration twice a day with morning and evening meals.
- Reduction of the risk of cardiovascular hospitalization.
- Reduction of the risk of hospitalization for atrial fibrillation.
- Treatment of patients with a history of paroxysmal or persistent af without severe heart failure and with one or more risk factors by administration twice a day with morning and evening meals.
- A method for the treatment of a patient suffering from a disease treatable with rotigotine, comprising applying the claimed transdermal delivery system (tds) to the skin of the patient.
- Treatment of restless legs syndrome by application of claimed transdermal delivery system.
- Treatment of signs and symptoms of parkinson's disease by application of claimed transdermal system.
- Pediatric use aged 1-11 years, gerd and erosive esophagitis.
- Treatment of a neurodegenerative disease or a symptom thereof.
- Treatment of hallucinations and delusions associated with parkinson's disease psychosis.
- Treatment of parkinson's disease psychosis.
- Treatment of psychosis or a symptom thereof.
- Treatment of psychosis.
- Maintenance treatment of bronchoconstriction in patients with chronic obstructive pulmonary disease (copd).
- Method of reversing the anticoagulant effect of dabigatran using idarucizumab.
- Prophylaxis or treatment of venous and arterial thrombotic disease.
- Pylera capsules, in combination with omeprazole are indicated for the treatment of patients with helicobacter pylori infection and duodenal ulcer disease to eradicate h. pylori.
- Treatment of patients with h. pylori infection and duodenal ulcer disease.
- Administration of 25-hydroxyvitamin d3 by controlled release.
- Treatment of secondary hyperparathyroidism in patients with stage 3 or 4 chronic kidney disease using controlled release, oral 25-hydroxyvitamin d.
- Use of controlled release 25-hydroxyvitamin d in treating secondary hyperparathyroidism in patients having chronic kidney disease.
- Use of extended release oral 25-hydroxyvitamin d3 in treating secondary hyperparathyroidism in adult patients having chronic kidney disease stage 3 or stage 4.
- Use of sustained release 25-hydroxyvitamin d in treating patients having 25-hydroxyvitamin d insufficiency or deficiency.
- Treatment of diseases or conditions by the use of a delayed release 1, 2, or 5 mg prednisone tablet.
- Treatment of diseases or conditions by the use of a delayed-release 1,2, or 5mg prednisone tablet.
- Treatment of pulmonary, gastrointestinal and/or rheumatological diseases or conditions by use of delayed release formulations of 1mg or 2mg prednisone.
- Treatment of rheumatoid arthritis by delayed release formulation of 1mg or 2mg of prednisone.
- Treatment of rheumatologic, allergic, pulmonary, gastrointestinal, dermatologic diseases or conditions by the use of a delayed release 5mg prednisone tablet.
- Treatment of male patient having a disease or condition responsive to a teratogenic drug.
- Use of revlimid (lenalidomide) for the treatment of mantle cell lymphoma (mcl).
- Use of revlimid (lenalidomide) for the treatment of multiple myeloma and transfusion-dependent anemia in myelodysplastic syndromes (mds).
- Use of revlimid (lenalidomide) for the treatment of multiple myeloma.
- Use of revlimid (lenalidomide) for the treatment of transfusion-dependent anemia in myelodysplastic syndromes (mds).
- Use of revlimid (lenalidomide) to inhibit the secretion of pro-inflammatory cytokines, including tumor necrosis factor alpha.
- Use of revlimid (lenalidomide) while preventing the exposure of a fetus or other contraindicated individual to revlimid (lenalidomide).
- Method of providing a therapeutically effective and stable median blood plasma level of levodopa.
- Treatment of parkinson's disease, post-encephalitic parkinsonism, and parkinsonism that may follow carbon monoxide intoxication or manganese intoxication.
- Treatment of parkinson's disease.
- Treatment of parkinsonism that may follow carbon monoxide intoxication or manganese intoxication.
- Treatment of post-encephalitic parkinsonism, and parkinsonism that may follow carbon monoxide intoxication or manganese intoxication.
- Treatment of post-encephalitic parkinsonism.
- Long - term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (copd).
- Administration of an inhalable powder comprising tiotropium via device.
- For the long-term, once-daily, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (copd), including chronic bronchitis and emphysema.
- Treatment of chronic obstructive pulmonary disease.
- Treatment of parkinson's disease.
- Treatment of parkinson's disease.
- Treatment of parkinson's disease.
- Treatment of parkinson's disease.
- Treatment of parkinson's disease.
- Treatment of parkinson's disease.
- Treatment of chronic obstructive pulmonary disease (copd), chronic bronchitis or emphysema.
- Use for maintenance treatment of chronic obstructive pulmonary disease.
- Use for the treatment of asthma in patients 6 years of age and older.
- First-line treatment of locally advanced unresectable or metastatic pancreatic cancer, in combination with gemcitabine.
- First-line treatment of metastatic non smal-cell lung cancer (nsclc) with egfr exon 19 deletions or exon 21 (l858r) substitution mutations as detected by an fda-approved test.
- Maintenance treatment in patients with locally advanced or metastatic nsclc who have not progressed on 1st-line treatment wth platinum-based chemotherapy.
- Maintenance treatment of patients with locally advanced or metastatic nsclc whose disease has not progressed after four cycles platinum-based chemotherapy.
- Treatment of locally advanced or metastatic non small-cell lung cancer (nsclc) after failure of at least one prior chemotherapy regimen.
- Method of treating an autoimmune disease selected from autoimmune polyarthritis and multiple sclerosis but not treating psoriatic arthritis.
- Method of treating multiple sclerosis.
- Acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (enl).
- Approval for marketing only under a special restriction program approved by fda called 'system for thalidomide education and prescribing safety' (s.t.e.p.s.).
- Maintenance therapy for prevention and supression of the cutaneous manifestations of enl recurrence.
- Method for delivering a drug to a patient in need of the drug, while avoiding the occurence of an adverse side effect known or suspected of being caused by said drug.
- Treatment of cutaneous manifestations of erythema nodosum leprosum (enl) in connection with a special program approved by fda called 'system for thalidomide education and prescribing safety' (s.t.e.p.s.).
- Treatment of male patient having a disease or condition responsive to a teratogenic drug.
- Use in combination with dexamethasone is indicated for the treatment of patients with newly diagnosed multiple myeloma.
- Use of thalidomide in combination with dexamethasone for the treatment of patients with newly diagnosed multiple myeloma.
- Use of thalidomide in treatment of cutaneous manifestations of erythema nodosum leprosum (enl).
- Use of thalidomide while preventing the exposure of a fetus or other contraindicated individual to thalidomide.
- Treatment of chronic obstructive pulmonary disease (copd) or chronic bronchitis.
- Treatment of chronic hepatitis b in adult patients with evidence of viral replication and either evidence of persistant elevations in serum aminotransferases (alt or ast) or histologically active disease.
- Treatment of chronic hepatitis b in adult patients.
- Long - term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (copd).
- The treatment or prevention of bronchospasm in adults and children 4 years of age and older with reversible obstructive airways disease and the prevention of exercised-induced bronchospasm in patients 4 years of age and older.
- Adjunctive treatment to levodopa/carbidopa in patients with parkinson's disease experiencing 'off' episodes.
- Treatment of signs and symptoms of dry eye disease (ded).
- Treatment of the signs symptoms of dry eye disease (ded).
- Treatment or secondary prevention of cardiovascular disease, cardiovascular events, or cerebrovascular events and risk-reduction of aspirin-associated gastric ulcers.
- Method of treating inflammatory conditions.
- Treatment of symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents 12 years of age and older. patent claims methods for treating a respiratory disease in a child.
Home Remedies for Disease
   Eat a high-fiber diet that include beans.
Mechanism - Fiber helps move food out of the stomach faster reducing reflux.RudyardKipling | November 5th, 2017
