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What is Alzheimer's disease?
Alzheimer's disease (AD) is the most common form of dementia among older people. Dementia is a brain disorder that seriously affects thinking and memory skills. If you have AD, it can impair your ability to reason or learn new skills until it becomes difficult to complete daily activities.
AD begins slowly over many years. It first involves the parts of the brain that control thought, memory, and language. It may be mistaken for normal memory changes with aging. However, AD is not a normal part of aging. The brain changes from the disease lead to symptoms that get worse over time.
What are the symptoms of Alzheimer's disease?People with AD may have trouble remembering recent events or the names of people they know. Behavior may vary from person to person and day to day. AD progresses in stages. Late-onset AD occurs in adults aged 65 and older, which is when most people develop the disease. Early-onset AD happens before age 65, which is not common.
Some symptoms of AD can include:
- Getting lost in familiar places
- Repeating the same question
- Not recognizing family members
- Having trouble speaking, reading, or writing
- Not taking care of yourself, such as not bathing or eating poorly
In AD, over time, symptoms get worse. Later on, people with AD may become anxious or aggressive or wander away from home. Eventually, they need total care. This can cause great stress for family members who must care for them.
Who is more likely to develop Alzheimer's disease?Researchers don't fully understand what causes AD. Age is the biggest risk factor. Your risk is also higher if a family member has had the disease. Although people who develop Alzheimer's don't always have a history of the disease in their families.
Researchers believe the causes of AD may be a combination of age-related changes in the brain, along with genetic, health, and lifestyle factors. Some medical conditions that are associated with a higher risk of AD include:
- Hearing loss
- Depression
- Mild cognitive impairment
- Concussion or other traumatic brain injury (TBI)
A related problem, mild cognitive impairment (MCI), causes more memory problems than normal for people of the same age. Many, but not all, people with MCI will develop AD.
How is Alzheimer's disease diagnosed?Some health conditions can cause memory loss or symptoms like AD. Talk with your health care provider if you're having noticeable changes in your memory. To determine if your symptoms are related to AD and not normal aging or another health condition, your provider may:
- Review your medical history and any medicines you're taking
- Conduct tests to check your memory, thinking, and problem-solving skills
- Ask about changes in behavior or personality
- Do tests to rule out any medical or mental health conditions
- Refer you to a provider that specializes in caring for older adults
- Recommend a neurologist, a doctor who specializes in treating diseases of the brain and nervous system
No treatment can stop the disease. However, some medicines may help keep symptoms from getting worse for a limited time.
Can Alzheimer's disease be prevented?You can't change some risk factors, like your age. But changing certain lifestyle factors may promote your brain health and help you live a healthier lifestyle overall. This can include to:
- Manage chronic health issues such as high blood pressure or hearing loss
- Get regular physical activity
- Eat a healthy diet
- Quit smoking (or don't start)
- Get enough sleep
- Develop strong social connections
NIH: National Institute on Aging
Normal FDA Approved Drugs
- Treatment of patients with relapsing forms of multiple sclerosis while managing the risk of teriflunomide and rosuvastatin interaction by limiting the rosuvastatin dose to no more than 10mg and/or administering about half the normal dose.
- Treatment of patients with relapsing forms of multiple sclerosis.
Home Remedies for Normal
   Licorice root has anti-inflammatory properties. Boil 1/2 ounce of licorice in 1 quart of water,... / ...days. Do not take licorice if you are pregnant, taking steroids or have low potassium levels. Low potassium levels can cause people to experience abnormal heart rhythms, high blood pressure, edema, lethargy, and/or congestive heart failure. The NIH has determined that there is insufficient data a... / ...if you have questions about possible interactions with a drug or supplement you take.
Mechanism - glycyrrhizinJlaiii | August 11th, 2020
Felter's Materia Medica on Normal
   A dried substance of mucilaginous character abstracted from several species of sea weeds (marine algae) growing along the coast of Asia. Most of... / ...rendering the best service when intestinal secretion is scanty, and in consequence, the feces are abnormally dry. From one teaspoonful to two heaping tablespoonfuls may be given once or twice a day in...2
   The dried flower-heads of Arnica montana, Linné (Nat. Ord. Compositae). A perennial of Siberia and the cooler parts of Europe; also found in... / ...ronic rheumatism, with cold skin and general debility it will stimulate the nervous system, restore normal warmth, re-establish restrained secretion, and thus relieve pain. In painful, bruised or suba...2
   ...d almost insensibly. Its regulation of the true secretion of the skin more nearly resembles that of normal or insensible perspiration than that caused by any other diaphoretic, corallorhiza possibly e......n of the skin. It is the most perfect diaphoretic we possess, so completely does it counterfeit the normal process of insensible perspiration. When the secretion of sweat is in abeyance it restores it......at is in abeyance it restores it; when colliquative it restrains it through its effect of promoting normal functioning of the sudoriparous glands. It may be indicated even though the patient be freely...2
   The dried leaves of (1) Barosma betulina (Thunberg), Bartling and Wendland, or of (2) Barosma serratifolia (Curtis), Willdenow. (Nat. Ord.... / ...rmint taste. Preparation.Specific Medicine Barosma. Dose, 1 to 60 drops. Specific Indications.Abnormally acid urine, with constant desire to urinate with but little relief from micturition; vesico... / ...have far better remedies. Buchu renders the urine dark, the latter depositing a brownish precipitate. It should never be used in acute disorders.2
   ... By improving the nutrition of the organ it is possible, in some instances, to correct structural abnormalities. Valvular troubles have been noted to gradually disappear under its prolonged administra......on, or in excitable or nervous individuals, the remedy relieves, because its tendency is to promote normal rhythmic action of the cardiac muscle. Aortic regurgitation is nearly always benefited by it ...2
   The root of Jateorhiza palmata (Lamarck), Miers (Nat. Ord. Menispermaceae). A climbing perennial, the Kalumb of the Southeast coast of Africa.... / ...etite remains good. It is largely ineffectual also when organic disease of the stomach prevents the normal outflow of gastric juice. When given, the small doses are preferable to large ones; and on ac...2
   The dried leaves of Erythroxylon Coca, Lamarck, and its varieties. (Nat. Ord. Erythroxylaceae.) South American Andes-Peru, Bolivia, and Chili.... / ...s a remedy to be used temporarily only for defective innervation. Though the appetite is apparently normal, digestion is imperfect, and there is an associated occipital and post-cervical pain, dizzine...2
   The dried, peeled pulp of the fruit of Citrullus Colocynthis (Linné,) Schrader. (Nat. Ord. Cucurbitaceae.) Mediterranean basin of Europe, Asia,... / ...rops; Water, 4 fluidounces. Mix. Sig.: One teaspoonful every 3 or 4 hours. Where there is a lack of normal secretion 5 drops of tincture of capsicum may be added to the mixture. With similar symptoms... / ...of the fifth nerve, when the characteristic cutting pain prevails. It should be given also when colicky pain precedes or accompanies amenorrhoea.2
   The rhizome and rootlets of Convallaria majalis, Linné (Nat. Ord. Liliaceae.) Common Name: Lily of the Valley. Principal Constituents.Two... / ...endant dyspnea and palpitation. When acting favorably the heart action becomes slower and stronger, normal rhythm is established, arterial pressure increased, respiration deepened, and the sense of su... / ...carditis and endocarditis, using it in fractional doses. Convallaria is of less service in stenosis of the aorta than in mitral disorders.2
   The rhizome and rootlets of Coptis trifolia, Salisbury. (Nat. Ord. Berberidaceae.) A plant of dark, cold swamps and sphagnous woods, found in Siberia, Greenland, and Iceland, and in... / ...complishes. Coptis is a good stimulant for atonic indigestion and dyspepsia, with deficiency in the normal flow of the peptic juices.2
   The bark and root-bark of Cornus florida, Linné. (Nat. Ord. Cornaceae.) A beautiful flowering tree of the United States. Dose, 5 to 60... / ...and general exhaustion. It is adapted to cases with feeble, relaxed tissues, with weak pulse and subnormal temperature. It has been suggested as useful in gastric ulcer. The preferred doses are from 5...2
   The unripe, full-grown fruits of Piper Cubeba, Linné, fil. (Nat. Ord. Piperaceae.) Java, Borneo, Sumatra, Prince of Wales Island, and other isles... / ...-like cutaneous eruption. It is eliminated by the urine and by the bronchial membranes, increasing normal and restraining abnormal secretions. It imparts its peculiar aromatic odor to the urine and t... / ...and hay fever. Care must be had not to blister the roof of the mouth, an untoward effect that is produced by the oil in a good quality of cubeba.2
   ...condition verges into exhaustion from over-stimulation of the heartmuscle and from a failure of the normal impulse conduction from auricle to ventricle. This is particularly evident when a person taki......nveniently studied under three heads, or stages, representing, however, but continuous action under normal and increased dosage rather than three actually separate conditions: (1) The therapeutic; (2)...2
   The leaves of Epigaea repens, Linné (Nat. Ord. Ericaceae). A small, trailing, shrubby plant of the eastern half of the United States. Dose, 5 to... / ...tion of the mucous membranes, vesical tenesmus, dysuria, and strangury. The urine is of higher than normal gravity and may contain, besides deposited salts, lithic acid gravel and broken down blood. I...2
   The rhizome of Eryngium yuccifolium, Michaux (Nat. Ord. Umbelliferae). A swamp and wet prairie plant found from Virginia to Texas. Dose, 10 to 40... / ... by inflammation and is of great value in acute cystitis, with deep-seated, burning pain, and where normal secretion is scanty and pathologic catarrh is more abundant. It acts well with apis or gelsem... / ...gastric irritation and mucous diarrhoea. In these cases the tongue is red and tender, nausea is marked, and there is a strong for food.2
Physician's Materia Medica on Normal
   Medicinally prescribed when the normal hydrochloric acid is de ficient in the gastric secretions as is the case in typhoid fever, in can cer of the stomach and in the gastric disturbances following alcoholic excesses. Dose of the oflicial diluted acid (10%), 0.6 to 1.6 c. c. (10 to 20 M).3
Physician's Therapeutics Memoranda on Normal
   As prophylactic measures, avoid all uncooked foods, especiaHy water that has not been boiled; sulphuric acid lemonade. In early stage, camphor, salol and... / ...doses of calomel. In stage of collapse stimulants and hot baths or hot water bed; strychnine and atropine hypodermatically; subcutaneous injection of normal salt solution.3
   For infants, a hot bath with remedies directed to the cause. which is often teething or... / ...powder); veratrum viride as arterial sedative; venesec tion if the case demands; Tonic Pilocarpine Compound as a diuretic, or submammary injection of normal salt solution. Control convul sions by cautious inhalations of chloroform, aided by chloral hydrate and potassium bromide. Morphine may be usef...3
   Empty the stomach. preferably by stomach tube, washing out with warm normal salt solution; opium (deodcrizui tincture), mucila ginous drinks. hot fomentations or poultice over epigastrium. Treat inflammatory symptoms on general principles.3
   Seek the cause and govern treatment accordingly. Distinguish articularly congestive from anemic headaches. In the former ergot and vascular sedatives are useful, in the latter stimulating remedies are indicated. See that excretions are normal, that the eyes are not under strain from errors of refraction. that hygenic conditions are good and that the patient takes suflicient exercise and recreation.3
   Hypodermatic injection of atropine and digitalin; application of heat by hot water bags, etc.; intravenous injection of sterilized normal salt solution3
   Physiological seminal emissions in unmarried men call for no treatment, although habitual chastily of thought, avoiding of late suppers and of leather beds will greatly diminish their frequency. Abnormally frequent emissions due to debility are to be treated by tonics—iron valerianate and lupulin is a good combination-—; if due to self abuse, impress patient with danger of the practice, and pre scribe bromides, hyoscine, a hard bed with light covering, etc.3
   Promote elimination by skin and bowels; Tonic Pilocarpine Com pound, N., B. & Co. with the hot pack for the former; elaterium for the latter. For convulsions, chloral and bromides (Bromanodyne) or chloroform (by inhalation). Vt!ut3S€3Ctl()n must be considered, with the alternative of intravenous injection of normal salt solution.3
References
2) Felter, Harvey Wickes, 1922, The Eclectic Materia Medica, Pharmacology and Therapeutics, Cincinnati, Ohio.
3) Nelson, Baker & Co., 1904, Physician's Handy Book of Materia Medica and Therapeustics, Detroit, Michigan.