Hydroxyurea
What is sickle cell disease (SCD)?
Sickle cell disease (SCD) is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. This changes the shape of the red blood cells. The cells are supposed to be disc-shaped, but instead they are crescent, or sickle, shaped.
The sickle-shaped cells are not flexible and cannot change shape easily. Many of them burst apart as they move through your blood vessels. The sickle cells usually only last 10 to 20 days, instead of the normal 90 to 120 days. Your body may have trouble making enough new cells to replace the ones that you lost. Because of this, you may not have enough red blood cells. This is a condition called anemia, and it can make you feel tired.
The sickle-shaped cells can also stick to vessel walls, causing a blockage that slows or stops the flow of blood. When this happens, oxygen can't reach nearby tissues. The lack of oxygen can cause attacks of sudden, severe pain, called pain crises. These attacks can occur without warning. If you get one, you might need to go to the hospital for treatment.
What causes sickle cell disease (SCD)?SCD is caused by a variant (change) in a gene that has instructions for your body to make one part of the hemoglobin. This changed gene is sometimes called a sickle cell gene. People with SCD are born with two sickle cell genes, one from each parent.
If you are born with one sickle cell gene, it's called sickle cell trait. People with sickle cell trait are generally healthy, but they can pass the defective gene on to their children.
Who is more likely to have sickle cell disease (SCD)?In the United States, most of the people with SCD are African Americans:
- About 1 in 13 Black or African American babies are born with sickle cell trait
- About 1 in every 365 Black or African American babies are born with sickle cell disease
SCD also affects some people who come from Hispanic, southern European, Middle Eastern, or Asian Indian backgrounds.
What are the symptoms of sickle cell disease (SCD)?People with SCD start to have signs of the disease during the first year of life, usually around 5 or 6 months of age. Early symptoms of SCD may include:
- Painful swelling of the hands and feet
- Fatigue or fussiness from anemia
- A yellowish color of the skin (jaundice) or the whites of the eyes (icterus)
The effects of SCD vary from person to person and can change over time. Most of the signs and symptoms of SCD are related to complications of the disease. They may include severe pain, anemia, organ damage, and infections.
How is sickle cell disease (SCD) diagnosed?A blood test can show if you have SCD or sickle cell trait. Genetic tests can tell if you have one or two copies of the sickle cell gene. Genetic tests can help confirm an SCD diagnosis if the results from blood tests are not clear.
All states now test newborns for SCD (as well as many other treatable conditions) as part of their screening programs. These programs help find the conditions early, so treatment can be started right away.
Health care providers can also diagnose SCD before a baby is born. That test uses a sample of amniotic fluid (the liquid in the sac surrounding the baby) or tissue taken from the placenta (the organ that brings oxygen and nutrients to the baby).
People who are thinking about having children can have the test to find out how likely it is that their children will have SCD.
What are the treatments for sickle cell disease (SCD)?There are many ways to manage sickle cell disease. Your medical team will probably include a hematologist, a doctor who specializes in blood diseases. You will work with your medical team to set up a treatment plan. Possible treatment options may include:
- Treatments that can help relieve symptoms and lessen complications, including:
- Hydroxyurea, a medicine to reduce sickling of red blood cells. This can help prevent serious symptoms of sickle cell disease. This medicine can be used in adults and in children as young as 9 months old. But this medicine is not safe during pregnancy.
- Voxelotor, another medicine to prevent the sickling of red blood cells. It can be used in adults and children ages 4 years and older.
- Pain relievers for acute or chronic pain.
- Antibiotics to try to prevent infections in younger children.
- Blood transfusions for severe anemia. If you have had some serious complications, such as a stroke, you may have transfusions to prevent more complications.
- Other treatments for specific complications, such as medicines to lower blood pressure and vitamins to treat a vitamin deficiency.
- Bone marrow or stem cell transplantation, which can cure SCD. Because these transplants are risky and can have serious side effects, they are usually only used in children with severe SCD. For the transplant to work, the bone marrow must be a close match. Usually, the best donor is a brother or sister.
- Gene therapies to treat SCD in people who are 12 years and older and have had repeated sickle cell crises. These new therapies involve taking some of your blood stem cells and either adding new DNA to them or changing their existing DNA. Then these cells are given back to you, and they can make a type of hemoglobin that is healthy. This can reduce the complications of SCD, including the SCD crises.
Complementary and alternative medicine (CAM) seems to help some people deal with pain caused by SCD. These types of CAM may lower your pain, especially if it is not well managed with medicines::
- Cognitive behavioral therapy (a type of counseling)
- Acupuncture
- Exercise or movement programs, such as yoga
- Massage
- Meditation and mindfulness practices
- Virtual reality, a computer-generated 3D environment you can see with special goggles
It's also important to take steps to keep yourself as healthy as possible:
- Get regular medical care
- Get your routine vaccinations
- Live a healthy lifestyle
- Avoid situations that may set off a pain crisis
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nih-developed Ai Algorithm Matches Potential Volunteers To Clinical Trials
researchers From Nlm And The National Cancer Institute Have Developed An Artificial Intelligence (ai) Algorithm To Help Speed Up The Process Of Matching Potential Volunteers To Relevant Clinical Research Trials Listed On Clinicaltrials.gov. A Study Published In nature Communications Found That The Ai Algorithm, Called Trialgpt, Could Successfully Identify Relevant Clinical Trials For Which A Person Is Eligible And Provide A Summary That Clearly Explains How That Person Meets The Criteria For Study Enrollment. The Researchers Concluded That This Tool Could Help Clinicians Navigate The Vast And Ever-changing Range Of Clinical Trials Available To Their Patients, Which May Lead To Improved Clinical Trial Enrollment And Faster Progress In Medical Research.
research At Nlm
nlm Division Of Intramural Research
Intramural Research At Nlm Consists Of The Development And Application Of
Computational Approaches To A Broad Range Of Problems In Biomedicine, Molecular Biology, And Health.
read Research Highlights | Meet Our Principal
Investigators | Explore Training
Opportunities
history Of Medicine At Nlm
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Efficient Health Care Information Exchange In The Us And Worldwide Is Made Possible By Nlm’s Work With It Data Standards.
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This Set Of Tooling Services Brings Together Many Health And Biomedical Vocabularies And Standards To Enable Interoperability Between Computer Systems.
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This Training Program Provides Biomedical And Clinical Informatics Training And Research Opportunities For Individuals At Various Stages In Their Career.
about Nlm
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The Library Started As A Shelf Of Books In The Surgeon General’s Office In 1836 But Has Grown To A Collection Of Millions Of Print And Electronic Resources.
-
The Diverse Centers, Divisions, Advisory Bodies And Other Organizational Units That Make Up Nlm Contribute In Myriad Ways To The Library’s Mission.
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this Ten Year Plan Outlines Nlm's Role In A Future Where Data And Information Transform And Accelerate Biomedical Discovery And Improve Health And Health Care.
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