Migraine
What are migraines?
Migraines are a recurring type of headache. They cause moderate to severe pain that is throbbing or pulsing. The pain is often on one side of your head. You may also have other symptoms, such as nausea and weakness. You may be sensitive to light and sound.
What causes migraines?Researchers believe that migraine has a genetic cause. There are also a number of factors that can trigger a migraine. These factors vary from person to person, and they include:
- Stress
- Anxiety
- Hormonal changes in women
- Bright or flashing lights
- Loud noises
- Strong smells
- Medicines
- Too much or not enough sleep
- Sudden changes in weather or environment
- Overexertion (too much physical activity)
- Tobacco
- Caffeine or caffeine withdrawal
- Skipped meals
- Medication overuse (taking medicine for migraines too often)
Some people have found that certain foods or ingredients can trigger headaches, especially when they are combined with other triggers. These foods and ingredients include:
- Alcohol
- Chocolate
- Aged cheeses
- Monosodium glutamate (MSG)
- Some fruits and nuts
- Fermented or pickled goods
- Yeast
- Cured or processed meats
About 12% of Americans get migraines. They can affect anyone, but you are more likely to have them if you:
- Are a woman. Women are three times more likely than men to get migraines.
- Have a family history of migraines. Most people with migraines have family members who have migraines.
- Have other medical conditions, such as depression, anxiety, bipolar disorder, sleep disorders, and epilepsy.
There are four different phases of migraines. You may not always go through every phase each time you have a migraine.:
- Prodome. This phase starts up to 24 hours before you get the migraine. You have early signs and symptoms, such as food cravings, unexplained mood changes, uncontrollable yawning, fluid retention, and increased urination.
- Aura. If you have this phase, you might see flashing or bright lights or zig-zag lines. You may have muscle weakness or feel like you are being touched or grabbed. An aura can happen just before or during a migraine.
- Headache. A migraine usually starts gradually and then becomes more severe. It typically causes throbbing or pulsing pain, which is often on one side of your head. But sometimes you can have a migraine without a headache. Other migraine symptoms may include
- Increased sensitivity to light, noise, and odors
- Nausea and vomiting
- Worsened pain when you move, cough, or sneeze
- Postdrome (following the headache). You may feel exhausted, weak, and confused after a migraine. This can last up to a day.
Migraines are more common in the morning; people often wake up with them. Some people have migraines at predictable times, such as before menstruation or on weekends following a stressful week of work.
How are migraines diagnosed?To make a diagnosis, your health care provider will:
- Take your medical history
- Ask about your symptoms
- Do a physical and neurological exam
An important part of diagnosing migraines is to rule out other medical conditions which could be causing the symptoms. So you may also have blood tests, an MRI or CT scan, or other tests.
How are migraines treated?There is no cure for migraines. Treatment focuses on relieving symptoms and preventing additional attacks.
There are different types of medicines to relieve symptoms. They include triptan drugs, ergotamine drugs, and pain relievers. The sooner you take the medicine, the more effective it is.
There are also other things you can do to feel better:
- Resting with your eyes closed in a quiet, darkened room
- Placing a cool cloth or ice pack on your forehead
- Drinking fluids
There are some lifestyle changes you can make to prevent migraines:
- Stress management strategies, such as exercise, relaxation techniques, and biofeedback, may reduce the number and severity of migraines. Biofeedback uses electronic devices to teach you to control certain body functions, such as your heartbeat, blood pressure, and muscle tension.
- Make a log of what seems to trigger your migraines. You can learn what you need to avoid, such as certain foods and medicines. It also help you figure out what you should do, such as establishing a consistent sleep schedule and eating regular meals.
- Hormone therapy may help some women whose migraines seem to be linked to their menstrual cycle
- If you have obesity, losing weight may also be helpful
If you have frequent or severe migraines, you may need to take medicines to prevent further attacks. Talk with your health care provider about which drug would be right for you.
Certain natural treatments, such as riboflavin (vitamin B2) and coenzyme Q10, may help prevent migraines. If your magnesium level is low, you can try taking magnesium. There is also an herb, butterbur, which some people take to prevent migraines. But butterbur may not be safe for long-term use. Always check with your health care provider before taking any supplements.
NIH: National Institute of Neurological Disorders and Stroke
Migraine FDA Approved Drugs
- Temporary reduction of fever.
- Temporary relief of minor aches and pains.
- Treatment/prevention of cardiovascular disease.
- Management of mild to moderate pain, management of moderate to severe pain as an adjunct to opioid analgesics in a critically ill patient with intravenous ibuprofen in need thereof.
- Management of mild to moderate pain, management of moderate to severe pain as an adjunct to opioid analgesics, reduction in fever through anti-inflammatory, analgesic, and antipyretic activity.
- Management of mild to moderate pain, management of moderate to severe pain as an adnunct to opioid analgesics, reduction in fever through anti inflammatory, analgesic, and antipyretic activity.
- Methods of treating pain, inflammation and/or fever in a critically ill patient with intravenous ibuprofen in need thereof.
- Methods of treating pain, inflammation and/or fever with intravenous ibuprofen such that mean arterial blood pressure does not increase the dosage interval.
- Acute treatment of migraine attacks with or without aura in adults.
- Treatment of epilepsy and/or migraine..
- Treatment of epilepsy.
- Treating migraine pain and one or more of a cluster of symptoms characteristic of a migraine attack symptoms being selected from photophobia, phonophobia nausea and functional disability.
LnkJun 17, 2004
PerrigoJan 16, 2004
Actavis Mid AtlanticApr 30, 1999
Amneal PharmsAug 18, 2011
Hi-tech PharmacalNov 3, 2016
Perrigo R And DSep 23, 2004
TaroJun 23, 2017
Aiping Pharm IncMay 5, 2017
Amneal Pharms NyFeb 17, 1987
Avema PharmaNov 26, 2003
Contract PharmacalJul 1, 1988
Granules IndiaDec 10, 2010
Granules India LtdOct 7, 2016
Marksans PharmaFeb 1, 2011
McneilMar 30, 1994
Merro PharmOct 2, 1987
OhmJul 15, 1986
Par PharmSep 24, 1986
Strides PharmaApr 4, 2011
Vintage PharmsApr 1, 1987
L Perrigo CoDec 16, 1998
Tris Pharma IncAug 31, 2009
Bionpharma IncMar 24, 2009
Humanwell PuracapJun 21, 2016
P And L Dev LlcJul 10, 2009
Sofgen PharmsSep 7, 2016
- Acute treatment of migraine by delivering a powdered substance comprising sumatriptan via a breath-powered delivery device.
- Acute treatment of migraine.
- Method of drug delivery via the nasal cavity.
- Treatment of migraine via delivery of sumatriptan via the nasal cavity.
- Treatment of migraine with or without aura.
- Acute treatment of migraine.
- Treatment of migraine.
- Treatment of epilepsy.
- Use of trokendi xr for prophylactic treatment of migraine.
- Use of trokendi xr for the treatment of epilepsy.
Home Remedies for Migraine
   Eat 1/4 cup of green pumpkin seeds (pepitas) daily.
Mechanism - increase levels of magnesiumBarbara | November 5th, 2017
   Apply a dab of peppermint oil or eucalyptus oil under the nose and on the temples to help relieve headache pain.Garrett | July 19th, 2018
Felter's Materia Medica on Migraine
   The whole plant of Chelidonium majus, Linné (Nat. Ord. Papaveraceae). Europe naturalized in waste places in the United States. Dose, 1 to 60... / ...ir the condition upon which they depend. When hemorrhoids, splenic congestion, dyspepsia, headache, migraine, supra-orbital neuralgias and cough are dependent mostly upon the liver disorders helped by...1
   The dried leaves of Erythroxylon Coca, Lamarck, and its varieties. (Nat. Ord. Erythroxylaceae.) South American Andes-Peru, Bolivia, and Chili.... / ...in-sudden nervous exhaustion and insomnia, in painful indigestion, headache from exhaustion, and in migraine. In all of these it should be used for but short periods, and any symptoms of cocainism sho...1
   A dried paste, chiefly consisting of the crushed or pounded seeds of Paullinia Cupana, Kunth (Nat. Ord. Sapindaceae), yielding not less than 4 per... / ...dications.Headache with pallor, weak circulation, the pain aggravated by exertion; sick headache (migraine), with cerebral anemia; menstrual headache, with cerebral anemia; mental exhaustion or depr... / ...oculi nerve, followed by headache, has been relieved by it. In headaches the doses of 20 to 30 drops of the specific medicine should be given.1
   The seeds of Cola verticillata, C. anomala and C. nitida (Nat. Ord. Sterculiaceae). A tree of western Africa. Dose, 5 to 30 grains. Common Names:... / ... in the drug to cause much astringency. Like caffeine it is useful in the neuralgia of debility, in migraine, smoker's heart, and cardiac irritability. These are all cases needing stimulation and of t... / ...to faint, poor appetite and digestion, great nervous irritability, and profound muscular debility.1
   The bark of the root of Piscidia piscipula, Jacquin (Nat. Ord. Leguminosae). West Indies and rarely in Florida. Dose, 5 to 60 grains. Common Name:... / ...0 drops. Specific Indications.Insomnia and nervous unrest; spasm, pain, and nervous irritability; migraine, neuralgia. Action and Toxicology.Jamaica dogwood controls pain and produces sleep by its... / ...the feeble it should be employed with caution on account of its tendency to produce convulsions, even though it may satisfactorily relieve pain.1
Physician's Materia Medica on Migraine
   Analgesic, antipyretic, antiseptic; a powerful depressant to the spinal nerve centers. Used especially in neuralgic and rheumatic affections to control pain. in migraine, in febrile conditions accom panied with pain. in delirium tremens, in insomnia and as a remedy for obstinate vomiting. Externally it is useful as a surgical dress ing, resembling iodoform in its action. Incompatible with bromides and iodides and with spirit of nitrous ether. It is advantageously combined with Caffeine which dim2
   A derivative of NITRO-PHENOL. Analgesic. antipyretic. Prescribed for relief of pain in acute rheumatism, sciatica, gastralgia, migraine, dysmenorrhea, neuralgia. etc.; to reduce temperature and promote diaphoresis in fevers, and for a specific influence in diabetes. Dose, 0.12 to 0.60 Grm. (2 to 10 grs.).2
References
2) Nelson, Baker & Co., 1904, Physician's Handy Book of Materia Medica and Therapeustics, Detroit, Michigan.
