Pilocarpine FDA Approved Drugs
ISOPTO CARPINE [Pilocarpine HydrochlorideC11H16N2O2ClH]
RX
- 1% (ophthalmic solution)
2% (ophthalmic solution)
4% (ophthalmic solution)
Novartis Pharms CorpJun 22, 2010
PILOCARPINE HYDROCHLORIDE [Pilocarpine HydrochlorideC11H16N2O2ClH]
RX
- 5mg (oral tablet)
7.5mg (oral tablet)
Allied Pharma IncDec 22, 2004
Impax LabsMar 31, 2006
LannettOct 14, 2005
Perrigo Pharma IntlNov 16, 2004
Impax LabsMar 31, 2006
LannettOct 14, 2005
Perrigo Pharma IntlNov 16, 2004
SALAGEN [Pilocarpine HydrochlorideC11H16N2O2ClH]
RX
- 5mg (oral tablet)
7.5mg (oral tablet)
Eisai IncMar 22, 1994
WARNING: Consult a licensed physician in the appropriate field for medical treatment and drug prescription. Do not self medicate.
WARNING: All medicines, drugs, plants, chemicals or medicial precedures below are for historical reference only. Many of these treatments are now known to be harmful and possibly fatal. Do not consume any plant, chemical, drug or otherwise without first consulting a licensed physician that practices medine in the appropriate field.
Felter's Materia Medica on Pilocarpine
PHYSOSTIGMAPHYSO4
The dried, ripe seed of Physostigma venenosum, Balfour (Nat. Ord. Leguminosae). A climbing perennial, native of Calabar, in the Gulf of Guinea, on... / ...r, ammonia, digitalis, and strychnine. Wood suggests the availability of the antagonizing effect of pilocarpine (which by some is regarded equally as antidotal as atropine) in doses proportionate to ... / ...drug has not therefore had a fair trial. It is one of the suggested antidotes for strychnine poisoning, the alkaloid being preferred. For all of1
The dried, ripe seed of Physostigma venenosum, Balfour (Nat. Ord. Leguminosae). A climbing perennial, native of Calabar, in the Gulf of Guinea, on... / ...r, ammonia, digitalis, and strychnine. Wood suggests the availability of the antagonizing effect of pilocarpine (which by some is regarded equally as antidotal as atropine) in doses proportionate to ... / ...drug has not therefore had a fair trial. It is one of the suggested antidotes for strychnine poisoning, the alkaloid being preferred. For all of1
PILOCARPUSPILOC
...Pernambuco Jaborandi, (2) Maranham Jaborandi. Principal Constituents.The powerful liquid alkaloid pilocarpine (C11H16N2O2); a colorless, viscid oil, isopilocarpine; a volatile oil chiefly pilocarp......ation.Specific Medicine Jaborandi. Dose, 1 to 60 drops. Derivatives.Pilocarpina Hydrochloridum, Pilocarpine Hydrochloride. Translucent, colorless and odorless crystals of a feebly bitter taste; ......ether. Dose, 1/12 to 1/6 grain by mouth; 1/24 to 1/8 grain (hypodermatically). Pilocarpinae Nitras, Pilocarpine Nitrate. Permanent, shining, odorless crystals, very soluble in water and less so in alc...1
...Pernambuco Jaborandi, (2) Maranham Jaborandi. Principal Constituents.The powerful liquid alkaloid pilocarpine (C11H16N2O2); a colorless, viscid oil, isopilocarpine; a volatile oil chiefly pilocarp......ation.Specific Medicine Jaborandi. Dose, 1 to 60 drops. Derivatives.Pilocarpina Hydrochloridum, Pilocarpine Hydrochloride. Translucent, colorless and odorless crystals of a feebly bitter taste; ......ether. Dose, 1/12 to 1/6 grain by mouth; 1/24 to 1/8 grain (hypodermatically). Pilocarpinae Nitras, Pilocarpine Nitrate. Permanent, shining, odorless crystals, very soluble in water and less so in alc...1
WARNING: All medicines, drugs, plants, chemicals or medicial precedures below are for historical reference only. Many of these treatments are now known to be harmful and possibly fatal. Do not consume any plant, chemical, drug or otherwise without first consulting a licensed physician that practices medine in the appropriate field.
Physician's Materia Medica on Pilocarpine
JABORANDI (Pilocarpus)PIJA2
The leaves of PILOCARPUS SELLOANUS, Eng. and other species of Pilocarpus. A powerful diuretic, sialagogue and expectorant, antagonistic in action to belladonna. Increases the mammary secretion; reduces temperature and depresses the circulation. Used in dropsies and wherever a powerful eliminant is indicated. Active principle, Pilocarpine, q. v.2
The leaves of PILOCARPUS SELLOANUS, Eng. and other species of Pilocarpus. A powerful diuretic, sialagogue and expectorant, antagonistic in action to belladonna. Increases the mammary secretion; reduces temperature and depresses the circulation. Used in dropsies and wherever a powerful eliminant is indicated. Active principle, Pilocarpine, q. v.2
PILOCARPINE
Alkaloid obtained from the leaves of various species of PILOCARPUS, and representing their medicinal activity. see Jaborandi. The alkaloid may be used to advantage in all cases where jaborandi is beneficial, and has besides in a remarkable degree the power of con tracting the pupil of the eye when applied locally. Solutions contain ing 1 to 4 grains to the fluidounce of the hydrochloride are much used by ophthalmologists for their myotic effect and to relieve intraocular tension, Dose, 0.001 to 2
Alkaloid obtained from the leaves of various species of PILOCARPUS, and representing their medicinal activity. see Jaborandi. The alkaloid may be used to advantage in all cases where jaborandi is beneficial, and has besides in a remarkable degree the power of con tracting the pupil of the eye when applied locally. Solutions contain ing 1 to 4 grains to the fluidounce of the hydrochloride are much used by ophthalmologists for their myotic effect and to relieve intraocular tension, Dose, 0.001 to 2
TONIC PILOCARPINE COMPOUND
A combination in which the powerful secernant action of Pilocarpine is secured without the depressing effects commonly produced by that remedy. A most eflicient agent in the treatment of anasarca and ascites. Each fluidrachm contains; Pilocarpine Hydrochloride, 1-32 gr.; Strychnine Sulphate, 1-64 gr.; Digitoxin, 1-500 gr.; Sparteine Sulphate. 1/8 gr.2
A combination in which the powerful secernant action of Pilocarpine is secured without the depressing effects commonly produced by that remedy. A most eflicient agent in the treatment of anasarca and ascites. Each fluidrachm contains; Pilocarpine Hydrochloride, 1-32 gr.; Strychnine Sulphate, 1-64 gr.; Digitoxin, 1-500 gr.; Sparteine Sulphate. 1/8 gr.2
WARNING: All medicines, drugs, plants, chemicals or medicial precedures below are for historical reference only. Many of these treatments are now known to be harmful and possibly fatal. Do not consume any plant, chemical, drug or otherwise without first consulting a licensed physician that practices medine in the appropriate field.
Physician's Therapeutics Memoranda on Pilocarpine
AMBLYOPIA
Ascertain the cause. If due to... / ...tional taint, use altera tives. notably potassium iodide. If from extreme debility, appropri ate tonils, especially strychnine; if from uremia, Tonic Pilocarpine Compound; if from auto-intoxication, a mercurial purge; ii from ex cess, Eupeptic Hypophosphites. glycerophosphates, strychnine and other ...2
Ascertain the cause. If due to... / ...tional taint, use altera tives. notably potassium iodide. If from extreme debility, appropri ate tonils, especially strychnine; if from uremia, Tonic Pilocarpine Compound; if from auto-intoxication, a mercurial purge; ii from ex cess, Eupeptic Hypophosphites. glycerophosphates, strychnine and other ...2
CONVULSIONS
For infants, a hot bath with remedies directed to the cause. which is often teething or... / ...hyd ragogue cathartics (elaterium, croton oil, com pound jalap powder); veratrum viride as arterial sedative; venesec tion if the case demands; Tonic Pilocarpine Compound as a diuretic, or submammary injection of normal salt solution. Control convul sions by cautious inhalations of chloroform, aided...2
For infants, a hot bath with remedies directed to the cause. which is often teething or... / ...hyd ragogue cathartics (elaterium, croton oil, com pound jalap powder); veratrum viride as arterial sedative; venesec tion if the case demands; Tonic Pilocarpine Compound as a diuretic, or submammary injection of normal salt solution. Control convul sions by cautious inhalations of chloroform, aided...2
DIPSOMANIA
The treatment must be largely moral, but sustaining agents such as coca are important. The remedies having most effect are salts of gold (especially Solution Gold and Arsenic Bromide, N., B. & Co.); pilocarpine, tartar emetic, lupulin and capsicum.2
The treatment must be largely moral, but sustaining agents such as coca are important. The remedies having most effect are salts of gold (especially Solution Gold and Arsenic Bromide, N., B. & Co.); pilocarpine, tartar emetic, lupulin and capsicum.2
DROPSY
General treatment depends on the cause, which may be in disease of the heart, of the kidneys or less commonly of the liver. For im mediate relief prescribe active diuretics if the st ate of the kidneys permits, the most eflicient being Tonic Pilocarpine Compound; digi talis, canadian hemp, squill (these acting primarily on the circula tion), or hydragogue cathartics, elaterium. compound jalap powder, magnesium sulphate (in concentrated solution) are efficient remedies.2
General treatment depends on the cause, which may be in disease of the heart, of the kidneys or less commonly of the liver. For im mediate relief prescribe active diuretics if the st ate of the kidneys permits, the most eflicient being Tonic Pilocarpine Compound; digi talis, canadian hemp, squill (these acting primarily on the circula tion), or hydragogue cathartics, elaterium. compound jalap powder, magnesium sulphate (in concentrated solution) are efficient remedies.2
JAUNDICE
Treatment is somewhat empirical, the remedies most used being sodium phosphate (20 to 120 grs. two or three times a day), hydrastis, iodoform, citric acid, pilocarpine and salol. When due to catarrh of the duct, calomel and sodium bicarbonate in divided doses followed by a saline cathartic.2
Treatment is somewhat empirical, the remedies most used being sodium phosphate (20 to 120 grs. two or three times a day), hydrastis, iodoform, citric acid, pilocarpine and salol. When due to catarrh of the duct, calomel and sodium bicarbonate in divided doses followed by a saline cathartic.2
NEPHRITIS, ACUTE
Prescribe at first aconite, calomel and sodium bicarbonate fol lowed by a saline cathartic; warm mucilaginous drinks, potassium citrate and Ze-an; Glyceroplasma over loins. If uremia is threaten ed, elaterium, Tonic Pilocarpine Compound, hot air baths to cause sweating. In later stages digitalis and squill, caffeine, compound spirit juniper, even cantharides in small doses.2
Prescribe at first aconite, calomel and sodium bicarbonate fol lowed by a saline cathartic; warm mucilaginous drinks, potassium citrate and Ze-an; Glyceroplasma over loins. If uremia is threaten ed, elaterium, Tonic Pilocarpine Compound, hot air baths to cause sweating. In later stages digitalis and squill, caffeine, compound spirit juniper, even cantharides in small doses.2
NIGHT SWEATS
The remedies most efficient are belladonna or atropine, camphoric acid, zinc oxide, pilocarpine (as a stimulant to the sweat-glands), sulphuric acid; as a lotion, solution of alum in water or dilute alco hol; diluted acetic acid.2
The remedies most efficient are belladonna or atropine, camphoric acid, zinc oxide, pilocarpine (as a stimulant to the sweat-glands), sulphuric acid; as a lotion, solution of alum in water or dilute alco hol; diluted acetic acid.2
PLEURITIS
General treatment for inflammation. Locally apply Glycero plasma, which is particularly useful... / ...pping the chest, to relieve pain, is bet ter. To remove effusion, salicylic acid or saline or hydragogue cathartics or active diuretics such as Tonic Pilocarpine Compound. N., B. & Co.; application to chest of tincture iodine or a mixture of the tincture with glycerin, with addition of guaiacol or o...2
General treatment for inflammation. Locally apply Glycero plasma, which is particularly useful... / ...pping the chest, to relieve pain, is bet ter. To remove effusion, salicylic acid or saline or hydragogue cathartics or active diuretics such as Tonic Pilocarpine Compound. N., B. & Co.; application to chest of tincture iodine or a mixture of the tincture with glycerin, with addition of guaiacol or o...2
TETANUS
Tetanus antitoxin should be administered at once, and convul sions combated by inhalations of chloroform or by chloral combined with potassium bromide (see Bromanodyne, Part I). Other remedies are cocaine or a combination of this with morphine and atropine, hypodermatically; Fowler’s solution; calabar bean; pilocarpine (the last to eliminate the toxin).2
Tetanus antitoxin should be administered at once, and convul sions combated by inhalations of chloroform or by chloral combined with potassium bromide (see Bromanodyne, Part I). Other remedies are cocaine or a combination of this with morphine and atropine, hypodermatically; Fowler’s solution; calabar bean; pilocarpine (the last to eliminate the toxin).2
UREMIA
Promote elimination by skin and bowels; Tonic Pilocarpine Com pound, N., B. & Co. with the hot pack for the former; elaterium for the latter. For convulsions, chloral and bromides (Bromanodyne) or chloroform (by inhalation). Vt!ut3S€3Ctl()n must be considered, with the alternative of intravenous injection of normal salt solution.2
Promote elimination by skin and bowels; Tonic Pilocarpine Com pound, N., B. & Co. with the hot pack for the former; elaterium for the latter. For convulsions, chloral and bromides (Bromanodyne) or chloroform (by inhalation). Vt!ut3S€3Ctl()n must be considered, with the alternative of intravenous injection of normal salt solution.2
References
1) Felter, Harvey Wickes, 1922, The Eclectic Materia Medica, Pharmacology and Therapeutics, Cincinnati, Ohio.
2) Nelson, Baker & Co., 1904, Physician's Handy Book of Materia Medica and Therapeustics, Detroit, Michigan.
2) Nelson, Baker & Co., 1904, Physician's Handy Book of Materia Medica and Therapeustics, Detroit, Michigan.