Renal
You have two kidneys, each about the size of your fist. They are near the middle of your back, just below the rib cage. Inside each kidney there are about a million tiny structures called nephrons. They filter your blood. They remove wastes and extra water, which become urine. The urine flows through tubes called ureters. It goes to your bladder, which stores the urine until you go to the bathroom.
Most kidney diseases attack the nephrons. This damage may leave kidneys unable to remove wastes. Causes can include genetic problems, injuries, or medicines. You have a higher risk of kidney disease if you have diabetes, high blood pressure, or a close family member with kidney disease. Chronic kidney disease damages the nephrons slowly over several years. Other kidney problems include:
- Cancer
- Cysts
- Stones
- Infections
Your doctor can do blood and urine tests to check if you have kidney disease. If your kidneys fail, you will need dialysis or a kidney transplant.
NIH: National Institute of Diabetes and Digestive and Kidney Diseases
Renal FDA Approved Drugs
- Emergency treatment of allergic reactions (type i), including anaphylaxis.
- Treatment of advanced hormone receptor positive, her2-negative breast cancer in combination with exemestane after failure of treatment with letrozole or anastrozole.
- Treatment of patients with progessive neuroendocrine tumors of pancreatic origin (pnet) that are unresectable, locally advanced or metastatic.
- Treatment of patients with tuberous sclerosis complex (tsc) who have subependymal giant cell astrocytoma (sega) that requires therapeutic intervention but cannot be curatively resected..
- Treatment of solid excretory system tumors; advanced renal cell carcinoma (rcc), after failure of treatment with sunitinib or sorafenib.
- Method of treating allergic reaction via injection.
- Method for chronic weight management by decreasing food intake in an individual who does not have severe renal impairment or esrd.
- Method for chronic weight management by decreasing food intake.
- Method for chronic weight management by inducing satiety in an individual who does not have severe renal impairment or esrd.
- Method for chronic weight management by inducing satiety.
- Method for chronic weight management by treating obesity in an individual who does not have severe renal impairment or esrd.
- Method for chronic weight management by treating obesity.
- Method for chronic weight management.
- Method for chronic wieght management by controlling weight gain.
- Use of belviq (lorcaserin hydrochloride) for chronic weight management by decreasing food intake in patients on a reduced-calorie diet and who have achieved greater than or equal to 5% weight loss by week 12 of treatment.
- Use of belviq (lorcaserin hydrochloride) for chronic weight management by inducing satiety in patients on a reduced-calorie diet and who have achieved a greater than or equal to 5% weight loss by week 12 of treatment.
- Use of belviq (lorcaserin hydrochloride) for chronic weight management by treating obesity in patients on a reduced-calorie diet and who have achieved a greater than or equal to 5% weight loss by week 12 of treatment.
- Use of belviq (lorcaserin hydrochloride) for chronic weight management in patients on a reduced-calorie diet and who have achieved a greater than or equal to 5% weight loss by week 12 of treatment.
- Method for chronic weight management by decreasing food intake in an individual who does not have severe renal impairment or esrd.
- Method for chronic weight management by decreasing food intake.
- Method for chronic weight management by inducing satiety in an individual who does not have severe renal impairment or esrd.
- Method for chronic weight management by inducing satiety.
- Method for chronic weight management by treating obesity in an individual who does not have severe renal impairment or esrd.
- Method for chronic weight management by treating obesity.
- Method for chronic weight management.
- Method for chronic wieght management by controlling weight gain.
- Use of lorcaserin hydrochloride for chronic weight management by decreasing food intake in patients on a reduced-calorie diet and who have achieved a greater than or equal to 5% weight loss by week 12 of treatment.
- Use of lorcaserin hydrochloride for chronic weight management by inducing satiety in patients on a reduced-calorie diet and who have achieved a greater than or equal to 5% weight loss by week 12 of treatment.
- Use of lorcaserin hydrochloride for chronic weight management by treating obesity in patients on a reduced-calorie diet and who have achieved a greater than or equal to 5% weight loss by week 12 of treatment.
- Use of lorcaserin hydrochloride for chronic weight management in patients on a reduced-calorie diet and who have achieved a greater than or equal to 5% weight loss by week 12 of treatment.
- Treatment of renal cell carcinoma.
- Emergency treatment of allergic reactions (type i), including anaphylaxis.
- Increasing mean arterial blood pressure in adult patients with hypotension associated with septic shock.
- Induction and maintenance of mydriasis during intraocular surgery.
Shire LlcNov 23, 2005
- To reduce serum phosphate in patients with end stage renal disease.
- Treatment of renal cell carcinoma.
- Prophylaxis of organ rejection in patients receiving allogeneic renal transplants.
- Treatment of advanced renal cell carcinoma.
- Treatment of carcinoma of the thyroid.
- Treatment of unresectable hepatocellular carcinoma, advanced renal cell carcinoma, or differentiated thyroid carcinoma..
- Treatment of unresectable hepatocellular carcinoma.
- Use as replacement solution, hemofiltration solution or hemodiafiltration solution in continuous renal replacement therapy.
- Use as replacement solution, hemofiltration solution or hemodiafiltration solution in continuous renal replacement therapy.
- Treatment of gastrointestinal stromal tumor with sunitinib.
- Treatment of protein kinase related disorders, such as gastrointestinal stromal tumors, renal cell carcinoma and advanced pancreatic neuroendocrine tumors, with sunitinib.
- Method of treating metastatic papillary renal cell carcinoma with temsirolimus..
- Method of treating papillary renal cell carcinoma with temsirolimus, in the absence of interferon alpha..
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-4 inhibitor in combination with pioglitazone.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-4 inhibitor in combination with sulfonlyurea.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidase-iv inhibitor in combination with metformin and/or a sulfonylurea.
- Method of treating type 2 diabetes mellitus by administering a dipeptidyl peptidaste-iv inhibitor.
- Method of treating type 2 diabetes mellitus by administering linagliptin in combination with insulin (with or without metformin and/or pioglitazone).
- Method of treating type 2 diabetes mellitus by administering linagliptin in combination with metformin.
- Method of treating type 2 diabetes mellitus by administering linagliptin.
- Method of treating type 2 diabetes mellitus in patients with severe chronic renal impairment and for whom metformin therapy is inappropriate by administering linagliptin.
- Method of treating type 2 diabetes mellitus in patients with severe chronic renal impairment and who are ineligible for metformin therapy by administering linagliptin.
- Treatment of type 2 diabetes mellitus.
- Prophylaxis of allograft rejection in adult patients receiving a liver transplant.
- Prophylaxis of organ rejection in adult patients at low-moderate immunologic risk receiving a renal transplant.
Felter's Materia Medica on Renal
   The decorticated dried root of Althaea officinalis, Linné (Nat. Ord. Malvaceae), a plant of salt marshes, river banks, and moist, sandy soils.... / ...l irritation, gastro-intestinal irritation and inflammation, and as a soothing drink in vesical and renal irritation and inflammation, acute cystitis, strangury and gravel. If the mucilage chiefly is ...1
   ...scle appears to be directly stimulated by it as are probably the arterial coats. Contraction of the renal arteries also takes place, so that while less blood passes at a time through the kidneys, the ...... cardiac pressure and arterial tonus, rather than to the increased intrinsic secreting power of the renal glomeruli, is the result of pharmacologic investigation in recent years, particularly the work...1
   The bark of the root of Aralia hispida, Linné (Nat. Ord. Araliaceae). A perennial undershrub of the eastern section of the United States. Dose, 1... / ...erapy.Sometimes a surprisingly effective agent for the removal of anasarca dependent chiefly upon renal inactivity or renal irritation. Moreover, it often fails. It is, however, useful as a mild ren...1
   The root of Aralia racemosa, Linné (Nat. Ord. Araliaceae). Found in rich woodlands and rocky situations in the eastern half of the United States. Common Names: Spikenard,... / ...apocryphal uses have been recorded for it, but outside of its good effects upon the respiratory and renal mucosa it has nothing to commend it. 1
   The dried bark of Aspidosperma Quebracho-blanco, Schlechtendal (Nat. Ord. Apocynaceae). An evergreen tree of Chili and the Argentine Republic.... / ...bed balance between the pulmonic circulation and the action of the heart. It is used in cardiac and renal asthma, emphysema, the dyspnoea of capillary bronchitis and of chronic pneumonia, advanced bro... / ...be given in water or plain or aromatized syrup. 1
   A balsam obtained from Toluifera Pereirae (Royle) Baillon. San Salvador in Central America; called Balsam of Peru because first exported to Europe... / ...the aged. It has a similar restraining effect upon catarrhal conditions of the gastrointestinal and renal tracts and is sometimes of advantage in stubbornly resisting gonorrhoea. Peru balsam should no...1
   The root of Berberis aquifolium, Pursh (Nat. Ord. Berberidaceae). Western United States from Colorado to the Pacific coast; cultivated also for... / ...digestion and assimilation; it activates the lymphatic system and ductless glands; and augments the renal secretion. It is a corrector and eliminator of depraved body fluids and assists thereby in goo...1
   The bark of the root and the berries of Berberis vulgaris, Linné (Nat. Ord. Berberidaceae). Europe, Asia, and the United States. Common Names:... / ...artic action it is of value in non-obstructive jaundice and in gastric and intestinal dyspepsia. In renal catarrh, occasioned by the presence of calculi, small doses may be given when there is burning...1
   ...ormally acid urine, with constant desire to urinate with but little relief from micturition; vesico-renal irritation, with catarrhal secretion; copious mucous or muco-purulent discharges; cystorrhea. ......ghtly quickens the circulation, and disinfects the urinary tract. It has but slight effect upon the renal organs, but such as it has is to stimulate slightly the output of both liquids and solids. It ...... potassium, digitalis, or spirit of nitrous ether, which make it more efficient for the purposes of renal depuration. Buchu disinfects the urinary tract, imparting its aroma to the urine, and is to be...1
   The fresh, green stems and the flowers of Selenicereus grandiflorus (L.) Britt. & Rose (and other Selenicereus speciesMM) (Cereus grandiflorus,... / ...ally permanent. In medicinal doses, cactus diminishes the frequency of the pulse, and increases the renal secretions, and is, therefore, sedative and diuretic. According to Scudder (Specific Medicatio... / ...organ were held with a strong band, it is often the most prompt of all cardiac remedies. It is a good remedy in the heart troubles produced by to1
   The seeds of Caffea arabica, Linné (Nat. Ord. Rubiaceae). Native of Arabia-Felix and Ethiopia; and extensively cultivated in Asia and America... / ...icle. Caffeine increases the output of both the solids and the fluids of the urine, by dilating the renal bloodvessels and by direct action upon the renal epithelia. The tissuewaste of the body is tho... / ...preferably without sugar or cream; for use in narcotic poisoning very strong, black coffee may be given freely, both by mouth and per rectum.1
   ... should not be used in states of great debility following grave illness, or the exanthems, nor when renal congestion or inflammation is present. Cantharis has been used in lotions to promote the growt......nic parenchymatous nephritis of inebriates, in pyelitis, and in chronic cystitis. Used carefully in renal medication it may accomplish great good; but when recklessly employed it is a dangerous medici...1
   The leaves or whole plant of Chimaphila umbellata (Linné, Nuttall. (Nat. Ord. Ericaceae.) North temperate region of the Northern Hemispheres, and... / ...r digestion, and has a good influence upon the processes of nutrition. In chronic affections of the renal tract with large mucous, muco-purulent or purulent discharges it is of the utmost value. Thick... / ...the disappearance of sugar in glycosuria. Chimaphila is a neglected remedy that may well take the place of other agents of questionable safety.1
   I. Cinnamomum Saigonicum. Dried bark of an undetermined species of Cinnamomum. Chiefly from China. II. Cinnamomum Zeylanicum. Dried bark of cultivated... / ... has given results which have been entirely satisfactory. Hemorrhages from the stomach, bowels, and renal organs are often promptly checked by the timely administration of cinnamon.1
   The dried, peeled pulp of the fruit of Citrullus Colocynthis (Linné,) Schrader. (Nat. Ord. Cucurbitaceae.) Mediterranean basin of Europe, Asia,... / ...ace or to the abdomen will purge as if given by the mouth. Colocynth, in small doses, increases the renal function. Therapy.Colocynth is a powerful hydragogue cathartic, but is seldom employed as su... / ...of the fifth nerve, when the characteristic cutting pain prevails. It should be given also when colicky pain precedes or accompanies amenorrhoea.1
Physician's Materia Medica on Renal
   The root of HYDRANGEA ARBORESCENs, Lin. Diuretic. antilithic; in large doses cathartic. Prescribed with good results in renal colic, especially when due to deposits of phosphates.2
   The dried glands or an extract prepared from the same have been found to possess the power of causing contraction of capillary blood vessels. Solutions applied locally blanch the mucous membrane promptly. Therapeutically such solutions are applied with excellent effect in epistaxis. in coryza and hay fever (applied to nasal mucous membrane), in trachoma, conjunctivitis and in uterine hemorrhages. Internally the remedy is useful in Addison’s disease, in neurasthenia, in climacteric disturbances...2
   Aconcentrated preparation of CORN SILK, q. v. An efficient lenitive diuretic stimulating the renal secretion without causing - local congestion or irritation. A valuable remedy in catarrhal in flammation of the bladder and in all cases where there is irritation of the genito-urinary tract. Ordinary adult dose 4 c. c. (a fluidrachm), representing about one ounce of fresh corn silk.2
Physician's Therapeutics Memoranda on Renal
   Pain, (renal colic) must be treated with chlorodyne, belladonna in full doses, morphine and atropine hypodermatically, cautious in hzilations of chloroform. Remedies depend on nature of the calculus.2
   Treat early stage as in acute bronchitis. The local congestion may be relieved by application of a 4 per cent. solution of cocaine, or a solution of suprarenal extract. Spray or vapor of camphor and menthol or use by inhaler of a little Phenol Camphor gives much relief. Alkal-Antiseptine with nasal douche is a useful remedy.2
   If dependent on vaso-motor relaxation, ergot, extract suprarenal glands; astringents, particularly gallic acid and rhus aromatica. If due to nervous irritability, belladonna, nervines, bromides. Tonics are generally indicated, particularly iron and strychnine.2
   In severe cases, surgical measures must be resorted to (plugging anterior and posterior nares).... / ...astringents, Monsel’s solution, vinegar) may be used, or else remedies that contract the capillaries (fluid extract ergot, anti pyrin, extract suprarenal capsule or internally fluid extract ergot). The hot foot bath to draw the blood away from the head, cold wa ter to nape of neck, raising the han...2
   Nourish patient by enemas so that stomach may have complete rest. Internally, silver nitrate and resorcin with codeine or morph ine, antacids, especially sodium bicarbonate with bismuth subcar bonate; counter-irritation by tincture iodine or mustard leaves; antiemetics as needed; for hematemesis, emulsion of oil turpentine, antipyrin, alum or other styptic; suprarenal extract. Bowels must be regulated by enemata.2
   In simple Goitre (Bronchocele), ointment of mercuric iodide or tincture iodine externally; creosotide or potassium iodide and extract of thymus gland internally. In Exophthalmic Goitre, belladonna, strophanthus. ergot and sparteine are among the remedies that have been found serviceable. Extract of suprarenal capsules promises good results.2
   Astringents, particularly Monsel’s Solution (3 minims well dilut ed), tincture ferric Chloride, tannin, opium and lead acetate; ice swallowed frequently; extract suprarenal capsules; ergot; distilled extract witch hazel.2
   General treatment the same as ilr incipient bronchitis. Locally, use frequently as a gargle A... / ...ight parts of hot water; paint the throat once or twice with tincture ferric chloride containing 5 grs. to the drachm of quinine sulphate; apply suprarenal extract to relieve congestion; gargle with a solution of potassium chlorate and ferric chloride; apply antipyrin by spray. In Chronic Pharyngiti...2
   The disease is one of non-assimilation, the remedies, 1st general tonics and nutrients; cod liver oil. quinine, copper arsenite, syrup ferrous iodide, Haemo-Mangan; 2d Bone lood; phosphorus. glycero phosphates, hypophosphites, lacto-phosphates, Eupeptic Hypophos phites, N., B. & Co. Thyroid extract and suprarenal extract have given good results. Improve hygienic condition of patient and prescribe massage and passive exercise when this is practicable.2
   Quinine in large doses. proceeded by calomel and a saline purge is the standard treatment. Hematuria is a contraindication. In chronic cases arsenic is the most important remedy. Intestinal or renal hemorrhages must be treated on general principles.2
   Some physicians prescribe as a specific remedy sodium salicylate (2 gr. doses every hour), others chloral (2 to 4 grs. every 2 to... / ...lyptol. For the itch ing, local application of olive oil containing a little carbolic acid, menthol or salicylic acid. Avoid anything likely to cause renal irri tation; particularly guard against exposure to cold during convales cence.2
References
2) Nelson, Baker & Co., 1904, Physician's Handy Book of Materia Medica and Therapeustics, Detroit, Michigan.