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What is Lewy body dementia (LBD)?

Lewy body dementia (LBD) is one of the most common types of dementia in older adults. Dementia is a loss of mental functions that is severe enough to affect your daily life and activities. These functions include:

  • Memory
  • Language skills
  • Visual perception (your ability to make sense of what you see)
  • Problem solving
  • Trouble with everyday tasks
  • The ability to focus and pay attention
What are the types of Lewy body dementia (LBD)?

There are two types of LBD: dementia with Lewy bodies and Parkinson's disease dementia.

Both types cause the same changes in the brain. And, over time, they can cause similar symptoms. The main difference is in when the cognitive (thinking) and movement symptoms start.

Dementia with Lewy bodies causes problems with thinking ability that seem similar to Alzheimer's disease. Later, it also causes other symptoms, such as movement symptoms, visual hallucinations, and certain sleep disorders. It also causes more trouble with mental activities than with memory.

Parkinson's disease dementia starts as a movement disorder. It first causes the symptoms of Parkinson's disease: slowed movement, muscle stiffness, tremor, and a shuffling walk. Later on, it causes dementia.

What causes Lewy body dementia (LBD)?

LBD happens when Lewy bodies build up in parts of the brain that control memory, thinking, and movement. Lewy bodies are abnormal deposits of a protein called alpha-synuclein. Researchers don't know exactly why these deposits form. But they do know that other diseases, such as Parkinson's disease, also involve a build-up of that protein.

Who is at risk for Lewy body dementia (LBD)?

The biggest risk factor for LBD is age; most people who get it are over age 50. People who have a family history of LBD are also at higher risk.

What are the symptoms of Lewy body dementia (LBD)?

LBD is a progressive disease. This means that the symptoms start slowly and get worse over time. The most common symptoms include changes in cognition, movement, sleep, and behavior:

  • Dementia, which is a loss of mental functions that is severe enough to affect your daily life and activities
  • Changes in concentration, attention, alertness, and wakefulness. These changes usually happen from day to day. But sometimes they can also happen throughout the same day.
  • Visual hallucinations, which means seeing things that are not there
  • Problems with movement and posture, including slowness of movement, difficulty walking, and muscle stiffness. These are called parkinsonian motor symptoms.
  • REM sleep behavior disorder, a condition in which a person seems to act out dreams. It may include vivid dreaming, talking in one's sleep, violent movements, or falling out of bed. This may be the earliest symptom of LBD in some people. It can appear several years before any other LBD symptoms.
  • Changes in behavior and mood, such as depression, anxiety, and apathy (a lack of interest in normal daily activities or events)

In the early stages of LBD, symptoms can be mild, and people can function fairly normally. As the disease gets worse, people with LBD need more help due to problems with thinking and movement. In the later stages of the disease, they often cannot care for themselves.

How is Lewy body dementia (LBD) diagnosed?

There isn't one test that can diagnose LBD. It is important to see an experienced doctor to get a diagnosis. This would usually be specialist such as a neurologist. The doctor will:

  • Do a medical history, including taking a detailed account of the symptoms. The doctor will talk to both the patient and caregivers.
  • Do physical and neurological exams
  • Do tests to rule out other conditions that could cause similar symptoms. These could include blood tests and brain imaging tests.
  • Do neuropsychological tests to evaluate memory and other cognitive functions

LBD can be hard to diagnose, because Parkinson's disease and Alzheimer's disease cause similar symptoms. Scientists think that Lewy body disease might be related to these diseases, or that they sometimes happen together.

It's also important to know which type of LBD a person has, so the doctor can treat that type's particular symptoms. It also helps the doctor understand how the disease will affect the person over time. The doctor makes a diagnosis based on when certain symptoms start:

  • If cognitive symptoms start within a year of movement problems, the diagnosis is dementia with Lewy bodies
  • If cognitive problems start more than a year after the movement problems, the diagnosis is Parkinson's disease dementia
What are the treatments for Lewy body dementia (LBD)?

There is no cure for LBD, but treatments can help with the symptoms:

  • Medicines may help with some of the cognitive, movement, and psychiatric symptoms
  • Physical therapy can help with movement problems
  • Occupational therapy may help find ways to more easily do everyday activities
  • Speech therapy may help with swallowing difficulties and trouble speaking loudly and clearly
  • Mental health counseling can help people with LBD and their families learn how to manage difficult emotions and behaviors. It can also help them plan for the future.
  • Music or art therapy may reduce anxiety and improve well-being

Support groups can also be helpful for people with LBD and their caregivers. Support groups can give emotional and social support. They are also a place where people can share tips about how to deal with day-to-day challenges.

NIH: National Institute of Neurological Disorders and Stroke


WARNING: All medicines, drugs, plants, chemicals or medicial precedures below are for historical reference only. Many of these treatments are now known to be harmful and possibly fatal. Do not consume any plant, chemical, drug or otherwise without first consulting a licensed physician that practices medine in the appropriate field.

Felter's Materia Medica on Similar

ABIES (Tsuga canadensis)TSCA
   The bark and prepared resinous exudate of Tsuga canadensis, Carriére (Abies canadensis, Michaux; Pinus canadensis, Linné). (Nat. Ord.... / ... it is not wholly without effect, acting much like but with less power than the oil of erigeron and similar preparations. Both the specific medicine and the oil may be incorporated into cough medicine...1

ACTÆA ALBA.
   The rhizome and rootlets of Actaea alba, Bigelow (Nat. Ord. Ranunculaceae). A perennial of the United States east of the Mississippi, abounding in... / ...ite Cohosh, White Baneberry, White Beads. Principal Constituents.—A non-acrid and non-bitter resin similar to that obtained from black cohosh (cimicifuga). Albumen, starch, sugar, and gum are present... / ...arising from derangement of the reproductive organs. Like cimicifuga it is useful in atonic indigestion of the nervous dyspepsia type. 1

APOCYNUM CANNABINUM
   ...school developed its specific uses in dropsy and affections of the heart and circulation. Like many similar drugs, the powder was employed as a sternutatory in the days when it was believed that such ......oyed nowadays as a cathartic, and then only in dropsical conditions, as other hydragogues have been similarly used. Such is the use of it advocated by the authors of the regular school of medicine, by...1

ARISÆMA TRIPHYLLUM
   The fresh corm of Arisaema triphyllum, Torre (Nat. Ord. Araceae). Common in damp woods and wet situations in North and South merica. Common Names:... / ...ere forms of sore throat, intensely painful, swollen and fetid, with deep or purplish-red membranes similar to that of the angina of scarlet fever. It is also useful in chronic laryngitis aggravated b... / ...may be given in drop doses every half to one hour, and a throat wash of one drachm of the tincture to a half glass of water may be used freely. 1

ASCLEPIAS INCARNATA
   The root of Asclepias incarnata, Linné (Nat. Ord. Asclepiadaceae). Common in damp and wet grounds throughout the United States. Dose, 1 to 60... / ... be substituted for digitalis in cases of edema dependent upon cardiac insufficiency. Its action is similar to that of foxglove, without the irritating effects upon the gastric membranes. In fact, in ...1

ASCLEPIAS TUBEROSA
   The root of Asclepias tuberosa, Linné (Nat. Ord. Asclepiadaceae). United States and Canada. Dose, 5 to 60 grains. Common Names: Pleurisy Root,... / ...n expectoration is scanty and dyspnea threatens, small doses of asclepias are helpful. It renders a similar service in dry, non-spasmodic asthma. The dose for these purposes should be about 5 drops of...1

BALSAMUM PERUVIANUM
   ...ins. As a stimulant to ulcers of low vitality and pus-oozing granulations following operations, and similar conditions in burns, abscesses, and wounds, the old-time use of the balsam has been revived ......g expectorant and is of some value to restrain secretion in the bronchorrhoea of the aged. It has a similar restraining effect upon catarrhal conditions of the gastrointestinal and renal tracts and is...1

BAPTISIA
   The recent root and leaves of Baptisia tinctoria, Robert Brown (Nat. Ord. Leguminosae), a perennial shrub-like plant, indigenous to North... / ...aptisia is very valuable in putrid ulcerations of the nasal passages—in fetid catarrh, ozaena, and similar disorders with stench and turgidity. Under these circumstances it overcomes the putrescency,...1

BELLADONNA (Atropa belladonna)ATROP
   ...quative sweating of phthisis and other debilitating diseases. The ointment and liniment may serve a similar purpose. This use of belladonna is less desirable, however, than other medication on account......belladonna relieves spasmodic dysmenorrhea and may be applied either in the vagina or the rectum. A similar application, with or without tannin or geranium, may be inserted into the vagina for painful...1

CAMPHORA
   ...iseptic liquids. In this manner, when triturated with chloral hydrate, menthol, phenol, thymol, and similar bodies, ideal liquid antiseptics are obtained for use upon wounds, neuralgic and other painf...... headache. A solution of camphor in liquid petrolatum (usually with menthol) is a popular spray for similar uses, and for laryngitis, pharyngitis, chronic nasal catarrh and hypertrophic rhinitis. The ...1

CARYOPHYLLUS
   ...ing followed by partial anaesthesia. It is typical of the class of volatile oils, most of which act similarly. It excites the salivary secretions and stimulates digestion by impressing the nerves of s......provoke gastro-enteritis. Oil of clove modifies the griping effects of many medicines. Eugenol acts similarly to oil of clove. Therapy.—External. Oil of Clove obtunds dental pain and sometimes earach...1

COCAERYTH5
   The dried leaves of Erythroxylon Coca, Lamarck, and its varieties. (Nat. Ord. Erythroxylaceae.) South American Andes-Peru, Bolivia, and Chili.... / ...functional maladies because of mere nervous discomfort than there would be in prescribing opium for similar purposes. Both lead to pernicious habits, with a train of miseries to which the victim final...1

COLOCYNTHIS
   The dried, peeled pulp of the fruit of Citrullus Colocynthis (Linné,) Schrader. (Nat. Ord. Cucurbitaceae.) Mediterranean basin of Europe, Asia,... / ...re is a lack of normal secretion 5 drops of tincture of capsicum may be added to the mixture. With similar symptoms minute doses act well in cholera infantum; in chronic diarrhoea with slimy stools a... / ...of the fifth nerve, when the characteristic cutting pain prevails. It should be given also when colicky pain precedes or accompanies amenorrhoea.1

COPTIS
   The rhizome and rootlets of Coptis trifolia, Salisbury. (Nat. Ord. Berberidaceae.) A plant of dark, cold swamps and sphagnous woods, found in... / ...e bitter and one that ought to be more generally used. It ranks with quassia, calumba, gentian, and similar agents in efficiency and may be used for many of the purposes for which hydrastis is employ...1

DIOSCOREA
   The rhizome of Dioscorea villosa, Linné (Nat. Ord. Dioscoreaceae). A vine found throughout the United States. Dose, 5 to 60 grains. Common Names:... / ...ter action that colic is relieved. Not alone does it succeed in cases of bilious colic, but it acts similarly in paroxysmal pain, with contraction of the muscular tissues, in cholera morbus, indigesti... / ...does not dissolve calculi. Usually, while there is much tenderness in cases requiring dioscorea, the distress is gradually relieved by pressure.1


WARNING: All medicines, drugs, plants, chemicals or medicial precedures below are for historical reference only. Many of these treatments are now known to be harmful and possibly fatal. Do not consume any plant, chemical, drug or otherwise without first consulting a licensed physician that practices medine in the appropriate field.

Physician's Materia Medica on Similar

ACID CARBOLIC (Phenol)
   A powerful antiseptic and germicide, also an energetic and rapid poison; used internally as an anti-emetic and a gastric and in testinal antiseptic. Locally it acts as an anesthetic and cauterant. The liquified acid is applied in full strength to cauterize or thoroughly cleanse infected wounds, followed by strongalcohol to neu tralize its devitalizing effects. Carbolated oil (10 grs. to the ounce) or a carbolated ointment of similar strength, is one of the best dress ings for burns, scalds and i2

B!SMUTH
   The compounds of Bismuth, although non-poisonous, have a marked antiseptic action which renders them valuable in medicine. They are used chiefly for their effect upon the mucous membrane of the stomach, having a soothing action when irritation of the mem brane exists. The insoluble compounds (subnitrate, snbcarbonate) have a similar action when applied topically to ulcerated surfaces or to the urethral or rectal mucous membrane. a. Bismuth and Ammonium Citrate. Beingsolubie, has greater astringe2

BROMOFORM
   A heavy liquid resembling chloroform in odor and taste and hav ing similar medicinal properties. It is prescribed especially as a remedy for spasmodic coughs, particularly for whooping cough. Dose, 0.06 to 0.30 c. c. (1 to 5 M).2

EUCAINE
   A synthetic alkaloid related to cocaine and having a similar local anesthetic action.2

GLYCERlN
   A dense fluid remarkable for its strong aflinity for moisture. It is hence of great use as a local depletant, especially to mucous membranes. It is thus applied to the cervix uteri to relieve conges tion and on a similar principle is used in the form of suppositories to cause the bowels to move. In diabetes mellitus, it is sometimes used in place of sugar as a sweetening agent in articles of food.2

LOVAGE
   The root of LEVISTICUM OFFICINALE, Koch. Aromatic, car minative; in hot infusion diaphoretic and emmenagogue. Similar in properties to Angelica.2

POTASSIUM NITRITE
   Produces effects similar to those of AMYL NITRITE. A valuable remedy in angina pectoris, in gastralgia and in the cases where nitroglycerin is commonly prescribed. Dose, 0-2 to 0.3 Grm. (3 to 5 grs.).2

ZINC CARBONATE
   The medicinal properties of the pure Carbonate are similar to those of the Oxide, q. v. In ointment it is much used in moist eczema, infantile intertrigo and similar affections of the skin, but the impure native Carbonate (Calamine) is more commonly used rather than the pure article.2

ZINC OLEATE
   The preparation so named is in fact usually a mixture of Oleate with Palmitate and Stearate, occurring in the form of a powder quite free from grittiness. Very useful in excessive perspiration of the feet, in moist eczema and similar conditions; applied by dusting over the surface, also in ointments used like Zinc ointment.2

ZINC SULPHATE
   In small doses produces effects similar to those of Zinc Oxide, which is, however, to be preferred for internal use. In large doses a prompt emetic especially suitable for use in cases of poisoning (except by corrosive poisons). Its solutions are astringent, stimulant and antiseptic, used in collyria, injections. etc. Dose as alterative or nervine, 0.015 to 0.06 Grm. (1/4 to 1 gr.); as emetic, 0.6 to 2.0 Grm. (10 to 30 grs.).2


WARNING: All medicines, drugs, plants, chemicals or medicial precedures below are for historical reference only. Many of these treatments are now known to be harmful and possibly fatal. Do not consume any plant, chemical, drug or otherwise without first consulting a licensed physician that practices medine in the appropriate field.

Physician's Therapeutics Memoranda on Similar

AMENORRHEA
   When due to anemia and debility, combinations of aloes with iron, In an otherwise healthy subject, apiol or... / ...ate), taken for at least two weeks beiore the regular time for menstruation. When due to “cold,” the sitz bath and hot infusions of pennyroyal or similar herbs; quinine with aloes or rhubarb. Cotton-root bark, ergot and similar agents are to be used always with due caution.2

BRONCHITIS
   In the incipient stage, quinine with a little Dover powder and a laxative may ward off the... / ...hese with henbane, heroine or codeine to allay excessive cough. As case progresses, use terpin hydrate or terebene, oil oi sandalwood, eucalyptol and similar remedies. Eucalyptol in spray or by inhalation is very eflicient. When there is hypersecretion, avoid ammonium chloride and use belladonna, st...2

CONJUNCTIVITIS
   In simple acute Conjunctivitis, boric acid, 10 grs. to the oz.’ in camphor water, or sodium borate of similar... / In simple acute Conjunctivitis, boric acid, 10 grs. to the oz.’ in camphor water, or sodium borate of similar strength; silver nit rate, 2 to 5 firs. to the oz.; in more severe cases a stronger solution of silver nitrate (10 grs. to the oz.) or mercur... / ...to fl. oz.; Iodosyl in powder; instilla tions of atropine solution with use of Iodosyl if ulcerations of cornea occur.2

CONVULSIONS
   For infants, a hot bath with remedies directed to the cause. which is often teething or... / ... castor oil being often more useful than any sedative. For adults chloral, or chloroform cautiously inhaled. If hysterical in character, valerian and similar agents. In Puerperal Convulsions, the first indication is to eliminate poisons from the system. Use the hot water pack (keeping head cool ) fo... / ...convulsions complicate labor, deliver child by instrumental means as soon as os is dilated.2

DIARRHEA
   See also Cholera Infantum, Cholera Morbus and Dysentery. Simple Atonic Diarrhea is best treated... / ...um combined with gastric and intestinal stimulants, carminatives and astringents. Chlorodyne is an efficient remedy, also the sun cholera mixture and similar formulas given under Astringents, Intestinal in Part II. Many cases of diarrhea are best treated in the outset with a mer urial (calomel, merc... / ...over abdomen. bismuth. silver nitrate, alum waters; intestinal antiseptics are often indicated.2

HEART DISEASE
   In organic diseases of the heart. remedies must be adapted to symptoms presented. Digitalis and similar agents are to be... / In organic diseases of the heart. remedies must be adapted to symptoms presented. Digitalis and similar agents are to be used when increase of blood pressure is desired; strophanthus when increas ed pressure will do harm, while yet an arterial st... / ...indicated, particularly nux vomica and iron. In cardiac failure, use diffusible stimulants, ammonia, ether and alcohol.2


References

1) Felter, Harvey Wickes, 1922, The Eclectic Materia Medica, Pharmacology and Therapeutics, Cincinnati, Ohio.
2) Nelson, Baker & Co., 1904, Physician's Handy Book of Materia Medica and Therapeustics, Detroit, Michigan.